Genetic variation in TNFA predicts protection from severe bacterial infections in patients with end-stage liver disease awaiting liver transplantation.

Senkerikova, Renata; de Mare-Bredemeijer, Emmeloes; Frankova, Sona; Roelen, Dave; Visseren, Thijmen; Trunecka, Pavel; Spicak, Julius; Metselaar, Herold; Jirsa, Milan; Kwekkeboom, Jaap; Sperl, Jan

Senkerikova, Renata; de Mare-Bredemeijer, Emmeloes; Frankova, Sona; Roelen, Dave; Visseren, Thijmen; Trunecka, Pavel; Spicak, Julius; Metselaar, Herold; Jirsa, Milan; Kwekkeboom, Jaap; Sperl, Jan.

Afiliação

Senkerikova R; Department of Hepatogastroenterology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
de Mare-Bredemeijer E; Department of Gastroenterology and Hepatology, Erasmus MC - University Medical Centre, Rotterdam, The Netherlands.
Frankova S; Department of Hepatogastroenterology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
Roelen D; Department of Immunohematology and Blood Transfusion, University Medical Centre, Leiden, The Netherlands.
Visseren T; Department of Gastroenterology and Hepatology, Erasmus MC - University Medical Centre, Rotterdam, The Netherlands.
Trunecka P; Department of Hepatogastroenterology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
Spicak J; Department of Hepatogastroenterology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
Metselaar H; Department of Gastroenterology and Hepatology, Erasmus MC - University Medical Centre, Rotterdam, The Netherlands.
Jirsa M; Laboratory of Experimental Hepatology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
Kwekkeboom J; Department of Gastroenterology and Hepatology, Erasmus MC - University Medical Centre, Rotterdam, The Netherlands.
Sperl J; Department of Hepatogastroenterology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic. Electronic address: jan.sperl@ikem.cz.

J Hepatol ; 60(4): 773-81, 2014 Apr.

Article em En | MEDLINE | ID: mdl-24361409

Assuntos

Infecções Bacterianas/genética; Infecções Bacterianas/prevenção & controle; Doença Hepática Terminal/complicações; Doença Hepática Terminal/genética; Transplante de Fígado; Fator de Necrose Tumoral alfa/genética; Adulto; Infecções Bacterianas/imunologia; Estudos de Coortes; Doença Hepática Terminal/imunologia; Feminino; Frequência do Gene; Estudos de Associação Genética; Marcadores Genéticos; Predisposição Genética para Doença; Variação Genética; Humanos; Masculino; Pessoa de Meia-Idade; Polimorfismo de Nucleotídeo Único; Estudos Retrospectivos; Receptor 4 Toll-Like/genética; Fator de Necrose Tumoral alfa/sangue

Palavras-chave

Inflammatory signalling; Innate immune cells; Liver cirrhosis; Neutrophil exhaustion; Toll-like receptor 4

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções Bacterianas / Transplante de Fígado / Fator de Necrose Tumoral alfa / Doença Hepática Terminal Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Hepatol Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: República Tcheca

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