The role of mTORC1 in regulating protein synthesis and skeletal muscle mass in response to various mechanical stimuli.
Rev Physiol Biochem Pharmacol
; 166: 43-95, 2014.
Article
em En
| MEDLINE
| ID: mdl-24442322
ABSTRACT
Skeletal muscle plays a fundamental role in mobility, disease prevention, and quality of life. Skeletal muscle mass is, in part, determined by the rates of protein synthesis, and mechanical loading is a major regulator of protein synthesis and skeletal muscle mass. The mammalian/mechanistic target of rapamycin (mTOR), found in the multi-protein complex, mTORC1, is proposed to play an essential role in the regulation of protein synthesis and skeletal muscle mass. The purpose of this review is to examine the function of mTORC1 in relation to protein synthesis and cell growth, the current evidence from rodent and human studies for the activation of mTORC1 signaling by different types of mechanical stimuli, whether mTORC1 signaling is necessary for changes in protein synthesis and skeletal muscle mass that occur in response to different types of mechanical stimuli, and the proposed molecular signaling mechanisms that may be responsible for the mechanical activation of mTORC1 signaling.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Biossíntese de Proteínas
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Músculo Esquelético
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Mecanotransdução Celular
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Complexos Multiproteicos
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Serina-Treonina Quinases TOR
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Rev Physiol Biochem Pharmacol
Ano de publicação:
2014
Tipo de documento:
Article