The fifth exon of the myelin proteolipid protein-coding gene is not utilized in the brain of jimpy mutant mice.
Gene
; 55(2-3): 333-7, 1987.
Article
em En
| MEDLINE
| ID: mdl-2444499
ABSTRACT
The jimpy mouse, an X-linked recessive dysmyelinating and demyelinating mutant, has been shown to contain abnormal myelin proteolipid protein (PLP) mRNA. To understand the molecular basis of the mutation, we analyzed the structure of PLP mRNA by an RNase-mapping procedure, using the probes specific to each exon of the mouse PLP gene. We found that the fifth exon of the PLP gene is not utilized in the jimpy.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças dos Roedores
/
Química Encefálica
/
RNA Mensageiro
/
Splicing de RNA
/
Éxons
/
Doenças Desmielinizantes
/
Camundongos Jimpy
/
Camundongos Mutantes Neurológicos
/
Proteínas da Mielina
Limite:
Animals
Idioma:
En
Revista:
Gene
Ano de publicação:
1987
Tipo de documento:
Article
País de afiliação:
Japão