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A polymorphism in human CD1A is associated with susceptibility to tuberculosis.
Seshadri, C; Thuong, N T T; Yen, N T B; Bang, N D; Chau, T T H; Thwaites, G E; Dunstan, S J; Hawn, T R.
Afiliação
  • Seshadri C; Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA, USA.
  • Thuong NT; Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.
  • Yen NT; Pham Ngoc Thach Hospital for Tuberculosis and Lung Disease, Ho Chi Minh City, Vietnam.
  • Bang ND; Pham Ngoc Thach Hospital for Tuberculosis and Lung Disease, Ho Chi Minh City, Vietnam.
  • Chau TT; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.
  • Thwaites GE; 1] Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam [2] Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Oxford, UK.
  • Dunstan SJ; 1] Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam [2] Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Oxford, UK.
  • Hawn TR; Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA, USA.
Genes Immun ; 15(3): 195-8, 2014.
Article em En | MEDLINE | ID: mdl-24500401
ABSTRACT
CD1 proteins are antigen-presenting molecules that evolved to present lipids rather than peptides to T cells. However, unlike major histocompatibility complex genes, CD1 genes show low rates of polymorphism and have not been clearly associated with human disease. We report that an intronic polymorphism in CD1A (rs411089) is associated with susceptibility to tuberculosis in two cohorts of Vietnamese adults (combined cohort odds ratio 1.78; 95% confidence interval 1.24-2.57; P=0.001). These data strengthen the hypothesis that CD1A-mediated lipid antigen presentation is important for controlling tuberculosis in humans.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polimorfismo Genético / Tuberculose / Antígenos CD1 / Predisposição Genética para Doença Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Humans País/Região como assunto: Asia Idioma: En Revista: Genes Immun Assunto da revista: ALERGIA E IMUNOLOGIA / BIOLOGIA MOLECULAR Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polimorfismo Genético / Tuberculose / Antígenos CD1 / Predisposição Genética para Doença Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Humans País/Região como assunto: Asia Idioma: En Revista: Genes Immun Assunto da revista: ALERGIA E IMUNOLOGIA / BIOLOGIA MOLECULAR Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Estados Unidos