Pesticide residues, heavy metals, and DNA damage in sentinel oysters Crassostrea gigas from Sinaloa and Sonora, Mexico.
J Toxicol Environ Health A
; 77(4): 169-76, 2014.
Article
em En
| MEDLINE
| ID: mdl-24555676
ABSTRACT
Pesticides and heavy metals were analyzed in sentinel Crassostrea gigas oysters placed in six aquaculture sites close to a contaminated agricultural region. Each site was sampled twice. Tests revealed the presence of organochlorine (OC) pesticides in the oysters at concentrations varying from 31.8 to 72.5 µg/kg for gamma-hexachlorocyclohexane (γ-HCH); from 1.2 to 3.1 µg/kg for dichlorodiphenyldichloroethylene (4,4-DDE); from 1.6 to 2.3 µg/kg for endosulfan I; and from 1.4 to 41.2 µg/kg for endosulfan II, as well as heavy metals in concentrations that exceeded Mexican tolerance levels (405.5 to 987.8 µg/g for zinc; 4.2 to 7.3 µg/g for cadmium; and 7.2 to 9.9 µg/g for lead). Significant levels of DNA damage in oyster hemocytes were also detected. There was a significant, positive correlation between genotoxic damage and concentration of nickel or the presence of endosulfan II. Cellular viability evaluated by cytotoxic analyses was found to be high at 80%. Marked inhibition in activity of acetylcholinesterase (AChE ) and induction of glutathione S-transferase (GST) activity was noted. Data demonstrated a significant relation between AChE activity inhibition and presence of endosulfan II, γ-HCH, copper, lead, and 4,4-DDE, as well as between AChE and GST activity at different sites.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Praguicidas
/
Poluentes Químicos da Água
/
Dano ao DNA
/
Resíduos de Praguicidas
/
Metais Pesados
/
Crassostrea
/
Mutagênicos
Limite:
Animals
País/Região como assunto:
Mexico
Idioma:
En
Revista:
J Toxicol Environ Health A
Assunto da revista:
SAUDE AMBIENTAL
/
TOXICOLOGIA
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
México