The effect of serine esterase inhibitors on ionophore-induced histamine release from human pulmonary mast cells.
Agents Actions
; 23(3-4): 198-200, 1988 Apr.
Article
em En
| MEDLINE
| ID: mdl-2455988
ABSTRACT
The serine proteases tryptase and chymase are present in human pulmonary mast cells. About 10-100 times more tryptase than chymase is found in these cells. However, a clear physiological role for both enzymes remains to be elucidated; angiotensin processing has been proposed as one possible function of chymase. A dose-dependent inhibition of A23187-induced histamine release from dispersed human lung mast cells was observed after pretreatment with the serine protease inhibitor diisopropylfluorophosphate (DFP) or the chymotrypsin-like enzyme inhibitor N-tosyl-L-phenylalanine chloromethylketone (TPCK) but not with the trypsin-like enzyme inhibitor N-tosyl-L-lysine chloromethylketone (TLCK). These results indicate that a chymase is probably an important factor in a late phase of human lung mast cell activation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Esterases
/
Liberação de Histamina
Limite:
Humans
Idioma:
En
Revista:
Agents Actions
Ano de publicação:
1988
Tipo de documento:
Article