Local control of repeated-dose rectal challenges in DNA/MVA-vaccinated macaques protected against a first series of simian immunodeficiency virus challenges.
J Virol
; 88(10): 5864-9, 2014 May.
Article
em En
| MEDLINE
| ID: mdl-24574408
ABSTRACT
Here, we report the results of a late boost and three additional series of simian immunodeficiency virus (SIV) challenges in seven DNA/modified vaccinia virus Ankara (MVA)-vaccinated rhesus macaques who resisted a first series of rectal challenges. During 29 additional challenges delivered over 2.3 years, all animals became infected. However, 13 blips of virus in six macaques and anamnestic Env-specific rectal IgA responses in three of the six suggested that local control of infections was occurring during the serial challenge.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Reto
/
Síndrome de Imunodeficiência Adquirida dos Símios
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Vírus da Imunodeficiência Símia
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Vacinas contra a SAIDS
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Imunidade nas Mucosas
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Vacinas de DNA
Limite:
Animals
Idioma:
En
Revista:
J Virol
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Estados Unidos