Rechallenging clozapine after neuroleptic malignant syndrome.
Psychiatr Q
; 85(3): 345-8, 2014 Sep.
Article
em En
| MEDLINE
| ID: mdl-24633526
ABSTRACT
Neuroleptic malignant syndrome (NMS) is a potentially fatal manifestation of antipsychotic use associated with symptoms that include mental status changes, muscle rigidity, fever and autonomic dysfunction. An occurrence of NMS with clozapine has been reported in the past but there are very few reports of successfully rechallenging the drug in individuals who have developed the syndrome. This case report discusses one of the few instances in literature where clozapine has been re-administered successfully to a patient without a reoccurrence of NMS. In conclusion, a rechallenge of clozapine after neuroleptic malignant syndrome can be done if care is taken to avoid concurrent use of lithium and other psychotropics, monitoring for NMS symptoms and titrating the dose upward slowly after a reasonable period of time.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antipsicóticos
/
Clozapina
/
Síndrome Maligna Neuroléptica
Limite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Psychiatr Q
Ano de publicação:
2014
Tipo de documento:
Article