Naringin ameliorates gentamicin-induced nephrotoxicity and associated mitochondrial dysfunction, apoptosis and inflammation in rats: possible mechanism of nephroprotection.

Sahu, Bidya Dhar; Tatireddy, Srujana; Koneru, Meghana; Borkar, Roshan M; Kumar, Jerald Mahesh; Kuncha, Madhusudana; Srinivas, R; Shyam Sunder, R; Sistla, Ramakrishna

Sahu, Bidya Dhar; Tatireddy, Srujana; Koneru, Meghana; Borkar, Roshan M; Kumar, Jerald Mahesh; Kuncha, Madhusudana; Srinivas, R; Shyam Sunder, R; Sistla, Ramakrishna.

Afiliação

Sahu BD; Medicinal Chemistry and Pharmacology Division, Indian Institute of Chemical Technology (IICT), Hyderabad 500 007, India.
Tatireddy S; National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500 037, India.
Koneru M; Medicinal Chemistry and Pharmacology Division, Indian Institute of Chemical Technology (IICT), Hyderabad 500 007, India.
Borkar RM; National Centre for Mass Spectrometry, Indian Institute of Chemical Technology (IICT), Hyderabad 500 007, India.
Kumar JM; CSIR-Centre for Cellular and Molecular Biology (CCMB), Hyderabad 500 007, India.
Kuncha M; Medicinal Chemistry and Pharmacology Division, Indian Institute of Chemical Technology (IICT), Hyderabad 500 007, India.
Srinivas R; National Centre for Mass Spectrometry, Indian Institute of Chemical Technology (IICT), Hyderabad 500 007, India.
Shyam Sunder R; Faculty of Pharmacy, Osmania University, Hyderabad 500 007, India.
Sistla R; Medicinal Chemistry and Pharmacology Division, Indian Institute of Chemical Technology (IICT), Hyderabad 500 007, India. Electronic address: sistla@iict.res.in.

Toxicol Appl Pharmacol ; 277(1): 8-20, 2014 May 15.

Article em En | MEDLINE | ID: mdl-24637089

Assuntos

Apoptose/efeitos dos fármacos; Flavanonas/farmacologia; Flavonoides/farmacologia; Gentamicinas/toxicidade; Rim/efeitos dos fármacos; Mitocôndrias/efeitos dos fármacos; Animais; Nitrogênio da Ureia Sanguínea; Creatinina/sangue; Gentamicinas/farmacologia; Mediadores da Inflamação/metabolismo; Rim/imunologia; Rim/patologia; Túbulos Renais/efeitos dos fármacos; Túbulos Renais/patologia; Peroxidação de Lipídeos/efeitos dos fármacos; Masculino; Oxirredução/efeitos dos fármacos; Estresse Oxidativo/efeitos dos fármacos; Ratos; Ratos Sprague-Dawley

Palavras-chave

Apoptosis; Gentamicin-induced nephrotoxicity; Inflammation; Mitochondrial dysfunction; Naringin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Flavonoides / Gentamicinas / Apoptose / Flavanonas / Rim / Mitocôndrias Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Revista: Toxicol Appl Pharmacol Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Índia

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