Inhibition of miR-25 improves cardiac contractility in the failing heart.

Wahlquist, Christine; Jeong, Dongtak; Rojas-Muñoz, Agustin; Kho, Changwon; Lee, Ahyoung; Mitsuyama, Shinichi; van Mil, Alain; Park, Woo Jin; Sluijter, Joost P G; Doevendans, Pieter A F; Hajjar, Roger J; Mercola, Mark

Wahlquist, Christine; Jeong, Dongtak; Rojas-Muñoz, Agustin; Kho, Changwon; Lee, Ahyoung; Mitsuyama, Shinichi; van Mil, Alain; Park, Woo Jin; Sluijter, Joost P G; Doevendans, Pieter A F; Hajjar, Roger J; Mercola, Mark.

Afiliação

Wahlquist C; 1] Department of Bioengineering, University of California, San Diego, and the Muscle Development and Regeneration Program, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA [2].
Jeong D; 1] The Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA [2].
Rojas-Muñoz A; Department of Bioengineering, University of California, San Diego, and the Muscle Development and Regeneration Program, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA.
Kho C; The Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Lee A; The Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Mitsuyama S; The Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
van Mil A; 1] Department of Bioengineering, University of California, San Diego, and the Muscle Development and Regeneration Program, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA [2] Department of Cardiology, University Medical Center Utrecht and IC
Park WJ; Global Research Laboratory, Gwangju Institute of Science and Technology, 123 Cheomdan-gwagiro, Buk-gu, Gwangju 500-712, South Korea.
Sluijter JP; Department of Cardiology, University Medical Center Utrecht and ICIN Netherlands Heart Institute, Heidelberglaan 100, room G02.523, 3584 CX Utrecht, The Netherlands.
Doevendans PA; Department of Cardiology, University Medical Center Utrecht and ICIN Netherlands Heart Institute, Heidelberglaan 100, room G02.523, 3584 CX Utrecht, The Netherlands.
Hajjar RJ; The Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Mercola M; Department of Bioengineering, University of California, San Diego, and the Muscle Development and Regeneration Program, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA.

Nature ; 508(7497): 531-5, 2014 Apr 24.

Article em En | MEDLINE | ID: mdl-24670661

Assuntos

Insuficiência Cardíaca/genética; Insuficiência Cardíaca/terapia; MicroRNAs/antagonistas & inibidores; Contração Miocárdica/efeitos dos fármacos; Animais; Cálcio/metabolismo; Dependovirus/genética; Modelos Animais de Doenças; Células HEK293; Coração/efeitos dos fármacos; Coração/fisiologia; Coração/fisiopatologia; Humanos; Cinética; Masculino; Camundongos; MicroRNAs/análise; MicroRNAs/genética; MicroRNAs/metabolismo; Miocárdio/metabolismo; Miócitos Cardíacos/metabolismo; Oligonucleotídeos Antissenso/genética; Oligonucleotídeos Antissenso/metabolismo; Oligonucleotídeos Antissenso/farmacologia; RNA Mensageiro/genética; RNA Mensageiro/metabolismo; Retículo Sarcoplasmático/metabolismo; ATPases Transportadoras de Cálcio do Retículo Sarcoplasmático/genética; ATPases Transportadoras de Cálcio do Retículo Sarcoplasmático/metabolismo; Análise de Sobrevida; Regulação para Cima/genética

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: MicroRNAs / Insuficiência Cardíaca / Contração Miocárdica Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: Nature Ano de publicação: 2014 Tipo de documento: Article

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