Incorporation of mouse APOBEC3 into murine leukemia virus virions decreases the activity and fidelity of reverse transcriptase.
J Virol
; 88(13): 7659-62, 2014 Jul.
Article
em En
| MEDLINE
| ID: mdl-24719421
ABSTRACT
APOBEC3 proteins are restriction factors that induce GâA hypermutation in retroviruses during replication as a result of cytidine deamination of minus-strand DNA transcripts. However, the mechanism of APOBEC inhibition of murine leukemia viruses (MuLVs) does not appear to be GâA hypermutation and is unclear. In this report, the incorporation of mA3 in virions resulted in a loss in virion reverse transcriptase (RT) activity and RT fidelity that correlated with the loss of virion-specific infectivity.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecções Tumorais por Vírus
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Vírion
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DNA Polimerase Dirigida por RNA
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Infecções por Retroviridae
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Citidina Desaminase
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Vírus da Leucemia Murina de Moloney
Limite:
Animals
Idioma:
En
Revista:
J Virol
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Itália