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Avidity of antibodies against infecting pneumococcal serotypes increases with age and severity of disease.
Cremers, Amelieke J H; Lut, Jonneke; Hermans, Peter W M; Meis, Jacques F; de Jonge, Marien I; Ferwerda, Gerben.
Afiliação
  • Cremers AJ; Laboratory of Pediatric Infectious Diseases, Department of Pediatrics, Radboudumc, Nijmegen, The Netherlands Amelieke.Cremers@radboudumc.nl.
  • Lut J; Laboratory of Pediatric Infectious Diseases, Department of Pediatrics, Radboudumc, Nijmegen, The Netherlands.
  • Hermans PW; Laboratory of Pediatric Infectious Diseases, Department of Pediatrics, Radboudumc, Nijmegen, The Netherlands.
  • Meis JF; Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands Department of Medical Microbiology, Radboudumc, Nijmegen, The Netherlands.
  • de Jonge MI; Laboratory of Pediatric Infectious Diseases, Department of Pediatrics, Radboudumc, Nijmegen, The Netherlands.
  • Ferwerda G; Laboratory of Pediatric Infectious Diseases, Department of Pediatrics, Radboudumc, Nijmegen, The Netherlands.
Clin Vaccine Immunol ; 21(6): 904-7, 2014 Jun.
Article em En | MEDLINE | ID: mdl-24759650
ABSTRACT
The incidence of invasive pneumococcal disease (IPD) rises with age. Among adult IPD patients, the avidity of antipneumococcal polysaccharide antibodies against the infecting serotype increased with age and severity of disease, indicating that susceptibility to IPD in the elderly may rather be due to flaws in other aspects of opsonophagocytosis.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imunoglobulina G / Anticorpos Antibacterianos / Afinidade de Anticorpos Limite: Humans Idioma: En Revista: Clin Vaccine Immunol Assunto da revista: ALERGIA E IMUNOLOGIA / TECNICAS E PROCEDIMENTOS DE LABORATORIO Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Holanda

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imunoglobulina G / Anticorpos Antibacterianos / Afinidade de Anticorpos Limite: Humans Idioma: En Revista: Clin Vaccine Immunol Assunto da revista: ALERGIA E IMUNOLOGIA / TECNICAS E PROCEDIMENTOS DE LABORATORIO Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Holanda