Translocation t(2;11) in CLL cells results in CXCR4/MAML2 fusion oncogene.
Blood
; 124(2): 259-62, 2014 Jul 10.
Article
em En
| MEDLINE
| ID: mdl-24855209
ABSTRACT
Recent investigations of chromosomal aberrations in chronic lymphocytic leukemia (CLL) led to a better understanding of the molecular causes of CLL. Here we report a rearrangement between MAML2 (mastermind-like protein 2) and CXCR4 (specific receptor for CXC chemokine stromal cell-derived factor-1) in CLL cells of a patient with a t(2;11)(q22.1;q21) chromosomal translocation. The rearrangement between MAML2 and CXCR4, created by a t(2;11)(q22.1;q21) translocation, results in a new fusion gene in which a portion of CXCR4 is linked to the MAML2 gene. This fusion gene encodes for CXCR4/MAML2 protein chimera in which the N-terminal basic domain of MAML2 is replaced by the N-terminal domain of CXCR4.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
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Translocação Genética
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Cromossomos Humanos Par 2
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Cromossomos Humanos Par 11
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Proteínas Nucleares
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Leucemia Linfocítica Crônica de Células B
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Proteínas de Fusão Oncogênica
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Receptores CXCR4
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Proteínas de Ligação a DNA
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Blood
Ano de publicação:
2014
Tipo de documento:
Article