Distinct mechanisms of induction of hepatic growth hormone resistance by endogenous IL-6, TNF-&#945;, and IL-1ß.

Zhao, Yueshui; Xiao, Xiaoqiu; Frank, Stuart J; Lin, Herbert Y; Xia, Yin

Distinct mechanisms of induction of hepatic growth hormone resistance by endogenous IL-6, TNF-α, and IL-1ß.

Zhao, Yueshui; Xiao, Xiaoqiu; Frank, Stuart J; Lin, Herbert Y; Xia, Yin.

Afiliação

Zhao Y; Key Laboratory for Regenerative Medicine, Ministry of Education, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China;
Xiao X; Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital, Chongqing Medical University, Chongqing, China; Xia.Yin@cuhk.edu.hk.
Frank SJ; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama and Endocrinology Section, Medical Service, Birmingham Veterans Affairs Medical Center, Birmingham, Alabama;
Lin HY; Program in Membrane Biology, Center for Systems Biology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Xia Y; Key Laboratory for Regenerative Medicine, Ministry of Education, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China; School of Biomedical Sciences Core Laboratory, The Chinese University of Hong Kong Shenzhen Research Institute, Shenzhen, China;

Am J Physiol Endocrinol Metab ; 307(2): E186-98, 2014 Jul 15.

Article em En | MEDLINE | ID: mdl-24895283

Assuntos

Hormônio do Crescimento/metabolismo; Interleucina-1beta/farmacologia; Interleucina-6/farmacologia; Fígado/metabolismo; Fator de Necrose Tumoral alfa/farmacologia; Animais; Células Cultivadas; Humanos; Inflamação/genética; Inflamação/metabolismo; Interleucina-1beta/metabolismo; Interleucina-6/metabolismo; Fígado/patologia; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Proteínas do Tecido Nervoso/genética; Moléculas de Adesão de Célula Nervosa/genética; Receptores da Somatotropina/genética; Receptores da Somatotropina/metabolismo; Fator de Necrose Tumoral alfa/metabolismo

Palavras-chave

GH receptor; IL-1ß; IL-6; SOCS3; TNF-α; growth hormone

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hormônio do Crescimento / Interleucina-6 / Fator de Necrose Tumoral alfa / Interleucina-1beta / Fígado Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: Am J Physiol Endocrinol Metab Assunto da revista: ENDOCRINOLOGIA / FISIOLOGIA / METABOLISMO Ano de publicação: 2014 Tipo de documento: Article

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