Alternative intronic polyadenylation generates the interleukin-6 trans-signaling inhibitor sgp130-E10.

Sommer, Jan; Garbers, Christoph; Wolf, Janina; Trad, Ahmad; Moll, Jens M; Sack, Markus; Fischer, Rainer; Grötzinger, Joachim; Waetzig, Georg H; Floss, Doreen M; Scheller, Jürgen

Sommer, Jan; Garbers, Christoph; Wolf, Janina; Trad, Ahmad; Moll, Jens M; Sack, Markus; Fischer, Rainer; Grötzinger, Joachim; Waetzig, Georg H; Floss, Doreen M; Scheller, Jürgen.

Afiliação

Sommer J; From the Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, 40225 Düsseldorf.
Garbers C; the Institute of Biochemistry, Medical Faculty, Christian-Albrechts-University, 24118 Kiel.
Wolf J; the Institute of Biochemistry, Medical Faculty, Christian-Albrechts-University, 24118 Kiel.
Trad A; the Institute of Biochemistry, Medical Faculty, Christian-Albrechts-University, 24118 Kiel.
Moll JM; From the Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, 40225 Düsseldorf.
Sack M; the Institute of Molecular Biotechnology, RWTH Aachen University, 52062 Aachen, and.
Fischer R; the Institute of Molecular Biotechnology, RWTH Aachen University, 52062 Aachen, and.
Grötzinger J; the Institute of Biochemistry, Medical Faculty, Christian-Albrechts-University, 24118 Kiel.
Waetzig GH; CONARIS Research Institute AG, 24118 Kiel, Germany.
Floss DM; From the Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, 40225 Düsseldorf.
Scheller J; From the Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, 40225 Düsseldorf, jscheller@uni-duesseldorf.de.

J Biol Chem ; 289(32): 22140-50, 2014 Aug 08.

Article em En | MEDLINE | ID: mdl-24973212

Assuntos

Receptor gp130 de Citocina/genética; Receptor gp130 de Citocina/metabolismo; Interleucina-6/metabolismo; Processamento Alternativo; Animais; Células CHO; Cricetinae; Cricetulus; Receptor gp130 de Citocina/química; Células HEK293; Humanos; Interleucina-6/química; Íntrons; Modelos Moleculares; Complexos Multiproteicos/química; Complexos Multiproteicos/metabolismo; Poliadenilação; Isoformas de Proteínas/química; Isoformas de Proteínas/genética; Isoformas de Proteínas/metabolismo; RNA Mensageiro/genética; Receptores de Interleucina-6/química; Receptores de Interleucina-6/metabolismo; Proteínas Recombinantes de Fusão/química; Proteínas Recombinantes de Fusão/genética; Proteínas Recombinantes de Fusão/metabolismo; Transdução de Sinais; Solubilidade

Palavras-chave

Alternative Splicing; Interleukin; Polyadenylation; Protein-tyrosine Kinase (Tyrosine Kinase); Signal Transduction

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Interleucina-6 / Receptor gp130 de Citocina Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2014 Tipo de documento: Article

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