Rab8a interacts directly with PI3KÎ³ to modulate TLR4-driven PI3K and mTOR signalling.

Luo, Lin; Wall, Adam A; Yeo, Jeremy C; Condon, Nicholas D; Norwood, Suzanne J; Schoenwaelder, Simone; Chen, Kaiwen W; Jackson, Shaun; Jenkins, Brendan J; Hartland, Elizabeth L; Schroder, Kate; Collins, Brett M; Sweet, Matthew J; Stow, Jennifer L

Luo, Lin; Wall, Adam A; Yeo, Jeremy C; Condon, Nicholas D; Norwood, Suzanne J; Schoenwaelder, Simone; Chen, Kaiwen W; Jackson, Shaun; Jenkins, Brendan J; Hartland, Elizabeth L; Schroder, Kate; Collins, Brett M; Sweet, Matthew J; Stow, Jennifer L.

Afiliação

Luo L; 1] Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia [2].
Wall AA; 1] Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia [2].
Yeo JC; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia.
Condon ND; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia.
Norwood SJ; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia.
Schoenwaelder S; 1] Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria 3004, Australia [2] Heart Research Institute & Charles Perkins Centre, The University of Sydney, Sydney, New South Wales 2006, Australia.
Chen KW; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia.
Jackson S; 1] Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria 3004, Australia [2] Heart Research Institute & Charles Perkins Centre, The University of Sydney, Sydney, New South Wales 2006, Australia.
Jenkins BJ; Centre for Innate Immunity and Infectious Diseases, MIMR-PHI Institute of Medical Research, Monash University, 27-31 Wright Street, Clayton, Victoria 3168, Australia.
Hartland EL; Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria 3010, Australia.
Schroder K; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia.
Collins BM; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia.
Sweet MJ; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia.
Stow JL; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia.

Nat Commun ; 5: 4407, 2014 Jul 15.

Article em En | MEDLINE | ID: mdl-25022365

Assuntos

Fosfatidilinositol 3-Quinases/metabolismo; Serina-Treonina Quinases TOR/metabolismo; Receptor 4 Toll-Like/metabolismo; Proteínas rab de Ligação ao GTP/metabolismo; Animais; Western Blotting; Ensaio de Imunoadsorção Enzimática; Espectrometria de Massas; Camundongos; Camundongos Knockout; Microscopia Eletrônica de Varredura; Fosfatidilinositol 3-Quinases/genética; Ligação Proteica; Células RAW 264.7; Transdução de Sinais/genética; Transdução de Sinais/fisiologia; Serina-Treonina Quinases TOR/genética; Receptor 4 Toll-Like/genética; Proteínas rab de Ligação ao GTP/genética

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosfatidilinositol 3-Quinases / Proteínas rab de Ligação ao GTP / Receptor 4 Toll-Like / Serina-Treonina Quinases TOR Limite: Animals Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2014 Tipo de documento: Article

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