A human fatty acid synthase inhibitor binds ß-ketoacyl reductase in the keto-substrate site.

Hardwicke, Mary Ann; Rendina, Alan R; Williams, Shawn P; Moore, Michael L; Wang, Liping; Krueger, Julie A; Plant, Ramona N; Totoritis, Rachel D; Zhang, Guofeng; Briand, Jacques; Burkhart, William A; Brown, Kristin K; Parrish, Cynthia A

Hardwicke, Mary Ann; Rendina, Alan R; Williams, Shawn P; Moore, Michael L; Wang, Liping; Krueger, Julie A; Plant, Ramona N; Totoritis, Rachel D; Zhang, Guofeng; Briand, Jacques; Burkhart, William A; Brown, Kristin K; Parrish, Cynthia A.

Afiliação

Hardwicke MA; 1] Oncology Research and Development, GlaxoSmithKline, Collegeville, Pennsylvania, USA. [2].
Rendina AR; 1] Platform Technology and Science, GlaxoSmithKline, Collegeville, Pennsylvania, USA. [2].
Williams SP; 1] Platform Technology and Science, GlaxoSmithKline, Research Triangle Park, North Carolina, USA. [2].
Moore ML; Oncology Research and Development, GlaxoSmithKline, Collegeville, Pennsylvania, USA.
Wang L; Platform Technology and Science, GlaxoSmithKline, Research Triangle Park, North Carolina, USA.
Krueger JA; Oncology Research and Development, GlaxoSmithKline, Collegeville, Pennsylvania, USA.
Plant RN; Oncology Research and Development, GlaxoSmithKline, Collegeville, Pennsylvania, USA.
Totoritis RD; Platform Technology and Science, GlaxoSmithKline, Collegeville, Pennsylvania, USA.
Zhang G; Platform Technology and Science, GlaxoSmithKline, Collegeville, Pennsylvania, USA.
Briand J; Platform Technology and Science, GlaxoSmithKline, Collegeville, Pennsylvania, USA.
Burkhart WA; Platform Technology and Science, GlaxoSmithKline, Research Triangle Park, North Carolina, USA.
Brown KK; Platform Technology and Science, GlaxoSmithKline, Collegeville, Pennsylvania, USA.
Parrish CA; Oncology Research and Development, GlaxoSmithKline, Collegeville, Pennsylvania, USA.

Nat Chem Biol ; 10(9): 774-9, 2014 Sep.

Article em En | MEDLINE | ID: mdl-25086508

Assuntos

3-Oxoacil-(Proteína Carreadora de Acil) Redutase/metabolismo; Inibidores Enzimáticos/metabolismo; Ácido Graxo Sintases/antagonistas & inibidores; Pirrolidinas/metabolismo; Pirrolidinas/farmacologia; Triazóis/metabolismo; Triazóis/farmacologia; 3-Oxoacil-(Proteína Carreadora de Acil) Redutase/química; Domínio Catalítico; Linhagem Celular Tumoral; Ácido Graxo Sintases/química; Humanos; Modelos Moleculares; Conformação Proteica; Difração de Raios X

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirrolidinas / Triazóis / Inibidores Enzimáticos / Ácido Graxo Sintases / 3-Oxoacil-(Proteína Carreadora de Acil) Redutase Limite: Humans Idioma: En Revista: Nat Chem Biol Assunto da revista: BIOLOGIA / QUIMICA Ano de publicação: 2014 Tipo de documento: Article

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