An alternative approach to confidence interval estimation for the win ratio statistic.
Biometrics
; 71(1): 139-145, 2015 Mar.
Article
em En
| MEDLINE
| ID: mdl-25156540
ABSTRACT
Pocock et al. (2012, European Heart Journal 33, 176-182) proposed a win ratio approach to analyzing composite endpoints comprised of outcomes with different clinical priorities. In this article, we establish a statistical framework for this approach. We derive the null hypothesis and propose a closed-form variance estimator for the win ratio statistic in all pairwise matching situation. Our simulation study shows that the proposed variance estimator performs well regardless of the magnitude of treatment effect size and the type of the joint distribution of the outcomes.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Algoritmos
/
Interpretação Estatística de Dados
/
Avaliação de Resultados em Cuidados de Saúde
/
Acidente Vascular Cerebral
/
Rivaroxabana
Tipo de estudo:
Clinical_trials
/
Diagnostic_studies
/
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Biometrics
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Estados Unidos