How does magnetization transfer influence mcDESPOT results?
Magn Reson Med
; 74(5): 1327-35, 2015 Nov.
Article
em En
| MEDLINE
| ID: mdl-25399771
ABSTRACT
PURPOSE:
A steady-state approach that was termed multicomponent driven equilibrium single pulse observation of T1 and T2 (mcDESPOT) has recently been proposed for myelin water fraction (fM) mapping in brain development and demyelinating diseases. However, fMs estimated by mcDESPOT are significantly higher than myelin water fraction derived from multiecho spin echo T2-decay curve approaches. Magnetization transfer (MT), enhanced by the use of short, relatively high amplitude radiofrequency (RF) pulses in mcDESPOT, may artifactually influence fM maps. Our goal was to investigate the role of MT in mcDESPOT.METHODS:
mcDESPOT data was collected twice from three healthy volunteers using short RF pulses with higher MT effect and long RF pulses with lower MT effect. MR parameters from 11 white and gray regions were compared using a paired student t-test. Whole slice difference images were also compared.RESULTS:
MT effects had a substantial influence on the signal generated by the balanced steady-state free procession sequences used in mcDESPOT. However, these MT effects were not clearly evident in the fM values determined by the conventional two-pool mcDESPOT analysis.CONCLUSION:
The signal generated from mcDESPOT is sensitive to MT, but the extracted myelin water fractions are relatively insensitive to changes of MT.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Processamento de Imagem Assistida por Computador
/
Encéfalo
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Imageamento por Ressonância Magnética
Limite:
Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
Magn Reson Med
Assunto da revista:
DIAGNOSTICO POR IMAGEM
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Canadá