Yttrium-90 radioembolization in patients with unresectable liver metastases: determining the factors that lead to treatment efficacy.
Hepatogastroenterology
; 61(134): 1529-34, 2014 Sep.
Article
em En
| MEDLINE
| ID: mdl-25436337
ABSTRACT
INTRODUCTION:
Locoregional treatments, such as radioembolization, can be used to treat patients with unresectable liver metastases. We aimed to determine the progression-free survival and factors that predict survival of patients with liver metastases whose response to selective internal radiation therapy (SIRT) with Y-90 was assessed by positron emission tomography-computed tomography (PET-CT). PATIENTS Our study included 78 liver cancer patients who were treated with Y-90 radioembolization.RESULTS:
The post-treatment response rates were as follows 7 patients (9%) had stable disease (SD), 26 patients (33.3%) had a partial response (PR), 4 patients (5.1%) had a complete response (CR). The median hepatic progression-free survival (HPFS) was 4.4 months while median overall survival was 10.1 months. Univariate analysis revealed that HPFS is significantly affected by international normalized ratio (INR) levels and age (Hazard Ratio(HR)=0.54 (95%CI0.30-096), P=0.034, HR=1.03(95%CI1.00-1.05), P=0.051). However, only INR levels retained significance with multivariate analysis (HR=0.53 (95%CI0.30-0.93), P=0.028), while age had limited significance (HR =1.02 (95% CI1.00-1.05), P=0.051).CONCLUSIONS:
We determined that Y-90 radioembolization is effective as a salvage therapy in patients with predominant liver metastases. For the first time, we showed that age and INR values reflecting the functional hepatic reserve can be used as positive predictive factors for HPFS.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Radioisótopos de Ítrio
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Compostos Radiofarmacêuticos
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Embolização Terapêutica
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Neoplasias Hepáticas
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Hepatogastroenterology
Ano de publicação:
2014
Tipo de documento:
Article