A novel role for the Pol I transcription factor UBTF in maintaining genome stability through the regulation of highly transcribed Pol II genes.

Sanij, Elaine; Diesch, Jeannine; Lesmana, Analia; Poortinga, Gretchen; Hein, Nadine; Lidgerwood, Grace; Cameron, Donald P; Ellul, Jason; Goodall, Gregory J; Wong, Lee H; Dhillon, Amardeep S; Hamdane, Nourdine; Rothblum, Lawrence I; Pearson, Richard B; Haviv, Izhak; Moss, Tom; Hannan, Ross D

Sanij, Elaine; Diesch, Jeannine; Lesmana, Analia; Poortinga, Gretchen; Hein, Nadine; Lidgerwood, Grace; Cameron, Donald P; Ellul, Jason; Goodall, Gregory J; Wong, Lee H; Dhillon, Amardeep S; Hamdane, Nourdine; Rothblum, Lawrence I; Pearson, Richard B; Haviv, Izhak; Moss, Tom; Hannan, Ross D.

Afiliação

Sanij E; Research Division, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria 3010, Australia; Department of Pathology, University of Melbourne, Parkville, Victoria 3010, Australia; elaine.sanij@pe
Diesch J; Research Division, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria 3010, Australia;
Lesmana A; Research Division, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria 3010, Australia;
Poortinga G; Research Division, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria 3010, Australia; Department of Medicine, University of Melbourne, Parkville, Victoria 3010, Australia;
Hein N; Research Division, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria 3010, Australia;
Lidgerwood G; Research Division, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia;
Cameron DP; Research Division, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria 3010, Australia;
Ellul J; Research Division, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria 3010, Australia;
Goodall GJ; Centre for Cancer Biology, SA Pathology and University of South Australia, Adelaide, South Australia 5000, Australia; Discipline of Medicine, The University of Adelaide, Adelaide, South Australia 5005, Australia; School of Molecular and Biomedical Science, The University of Adelaide, Adelaide, South
Wong LH; Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia;
Dhillon AS; Research Division, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria 3010, Australia; Department of Pathology, University of Melbourne, Parkville, Victoria 3010, Australia;
Hamdane N; Department of Molecular Biology, Medical Biochemistry and Pathology, Faculty of Medicine, Laval University, Québec, QC, G1V 0A6, Canada; St-Patrick Research Group in Basic Oncology, Québec University Hospital Research Centre, Québec, QC, G1R 3S3, Canada;
Rothblum LI; Department of Cell Biology, University of Oklahoma College of Medicine, Oklahoma City, Oklahoma 73104, USA;
Pearson RB; Research Division, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria 3010, Australia; Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
Haviv I; Department of Pathology, University of Melbourne, Parkville, Victoria 3010, Australia; Faculty of Medicine, Bar-Ilan University, Zfat, 13100, Israel;
Moss T; Department of Molecular Biology, Medical Biochemistry and Pathology, Faculty of Medicine, Laval University, Québec, QC, G1V 0A6, Canada; St-Patrick Research Group in Basic Oncology, Québec University Hospital Research Centre, Québec, QC, G1R 3S3, Canada;
Hannan RD; Research Division, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria 3010, Australia; Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia

Genome Res ; 25(2): 201-12, 2015 Feb.

Article em En | MEDLINE | ID: mdl-25452314

Assuntos

Regulação da Expressão Gênica; Instabilidade Genômica; Proteínas Pol1 do Complexo de Iniciação de Transcrição/metabolismo; RNA Polimerase II/genética; RNA Polimerase I/genética; Transcrição Gênica; Animais; Sítios de Ligação; Linhagem Celular Transformada; Cromatina/metabolismo; Imunoprecipitação da Cromatina; Biologia Computacional; Dano ao DNA; Técnicas de Silenciamento de Genes; Sequenciamento de Nucleotídeos em Larga Escala; Histonas/genética; Humanos; Camundongos; Família Multigênica; Células NIH 3T3; Nucleossomos/metabolismo; Proteínas Pol1 do Complexo de Iniciação de Transcrição/genética; Ligação Proteica; Sítio de Iniciação de Transcrição

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transcrição Gênica / RNA Polimerase I / RNA Polimerase II / Regulação da Expressão Gênica / Proteínas Pol1 do Complexo de Iniciação de Transcrição / Instabilidade Genômica Limite: Animals / Humans Idioma: En Revista: Genome Res Assunto da revista: BIOLOGIA MOLECULAR / GENETICA Ano de publicação: 2015 Tipo de documento: Article

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