Immunologic basis for allopurinol-induced severe cutaneous adverse reactions: HLA-B*58:01-restricted activation of drug-specific T cells and molecular interaction.

Lin, Chia-Hsien; Chen, Jung-Kuei; Ko, Tai-Ming; Wei, Chun-Yu; Wu, Jer-Yuarn; Chung, Wen-Hung; Chen, Shih-Yang; Liao, You-Di; Hung, Shuen-Iu; Chen, Yuan-Tsong

Lin, Chia-Hsien; Chen, Jung-Kuei; Ko, Tai-Ming; Wei, Chun-Yu; Wu, Jer-Yuarn; Chung, Wen-Hung; Chen, Shih-Yang; Liao, You-Di; Hung, Shuen-Iu; Chen, Yuan-Tsong.

Afiliação

Lin CH; Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Chen JK; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Ko TM; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Wei CY; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Wu JY; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Chung WH; Department of Dermatology, Chang Gung Memorial Hospital, Taipei, Taiwan.
Chen SY; Center of Gout, Country Hospital, Taipei, Taiwan.
Liao YD; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Hung SI; Institute of Pharmacology, School of Medicine, National Yang-Ming University, Taipei, Taiwan; Infection and Immunity Research Center, National Yang-Ming University, Taipei, Taiwan. Electronic address: sihung@ym.edu.tw.
Chen YT; Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. Electronic address: chen0010@ibms.sinica.edu.tw.

J Allergy Clin Immunol ; 135(4): 1063-1065.e5, 2015 Apr.

Article em En | MEDLINE | ID: mdl-25458913

Assuntos

Alopurinol/efeitos adversos; Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/imunologia; Antígenos HLA-B/imunologia; Linfócitos T/imunologia; Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/genética; Antígenos HLA-B/genética; Humanos; Ativação Linfocitária/imunologia; Farmacogenética; Especificidade do Receptor de Antígeno de Linfócitos T; Linfócitos T/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T / Antígenos HLA-B / Alopurinol / Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos Limite: Humans Idioma: En Revista: J Allergy Clin Immunol Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Taiwan

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