Loss of calcitonin receptors: a genetically transmitted defect in rats with high incidence of C-cell tumors.
Cancer Res
; 49(18): 5199-202, 1989 Sep 15.
Article
em En
| MEDLINE
| ID: mdl-2548716
C-cell tumors (medullary thyroid carcinoma) occur in humans and several other mammalian species. This tumor develops spontaneously with a high incidence (50%) in old Wag/Rij (Wistar-derived strain) rats. We have recently shown that calcitonin binding sites, which are present in the Wistar rats, are lost from renal medulla of the Wag/Rij rats before they reach the age of 1 month. In the present work, we investigated the distribution of calcitonin binding sites in the kidneys of first and second generation hybrids of Wistar x Wag/Rij rats. The absence of calcitonin binding sites from the renal medullas of 25% of F2 hybrids indicates that the deficiency is inherited in a Mendelian fashion and opens the way to establishing inbred strains lacking renal medullary calcitonin binding sites.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Calcitonina
/
Neoplasias da Glândula Tireoide
/
Receptores de Superfície Celular
Tipo de estudo:
Incidence_studies
/
Risk_factors_studies
Limite:
Animals
Idioma:
En
Revista:
Cancer Res
Ano de publicação:
1989
Tipo de documento:
Article
País de afiliação:
França