Conjugation of PolyPEG to interferon alpha extends serum half-life while maintaining low viscosity of the conjugate.

Podobnik, B; Helk, B; Smilovic, V; Skrajnar, S; Fidler, K; Jevsevar, S; Godwin, A; Williams, P

Podobnik, B; Helk, B; Smilovic, V; Skrajnar, S; Fidler, K; Jevsevar, S; Godwin, A; Williams, P.

Afiliação

Podobnik B; Sandoz Biopharmaceuticals, Menges, Lek Pharmaceuticals d.d., Kolodvorska 27, SI-1234 Menges, Slovenia.
Helk B; Novartis Pharma AG, CH-4056 Basel, Switzerland.
Smilovic V; Sandoz Biopharmaceuticals, Menges, Lek Pharmaceuticals d.d., Kolodvorska 27, SI-1234 Menges, Slovenia.
Skrajnar S; Sandoz Biopharmaceuticals, Menges, Lek Pharmaceuticals d.d., Kolodvorska 27, SI-1234 Menges, Slovenia.
Fidler K; Sandoz Biopharmaceuticals, Menges, Lek Pharmaceuticals d.d., Kolodvorska 27, SI-1234 Menges, Slovenia.
Jevsevar S; Sandoz Biopharmaceuticals, Menges, Lek Pharmaceuticals d.d., Kolodvorska 27, SI-1234 Menges, Slovenia.
Godwin A; §PolyTherics Ltd, Babraham Research Campus, Babraham, Cambridge CB22 3AT, United Kingdom.
Williams P; â¥PolyTherics Ltd, Unit 4, Vanguard Centre, University of Warwick Science Park, Coventry, CV4 7EZ, United Kingdom.

Bioconjug Chem ; 26(3): 452-9, 2015 Mar 18.

Article em En | MEDLINE | ID: mdl-25629733

Assuntos

Interferon-alfa/sangue; Interferon-alfa/química; Polietilenoglicóis/química; Polietilenoglicóis/metabolismo; Animais; Feminino; Células HEK293; Meia-Vida; Humanos; Ratos; Ratos Wistar; Viscosidade

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polietilenoglicóis / Interferon-alfa Limite: Animals / Female / Humans Idioma: En Revista: Bioconjug Chem Assunto da revista: BIOQUIMICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Eslovênia

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