[Brain mechanisms of depression--preliminary evidence from fMRI studies].
Seishin Shinkeigaku Zasshi
; 116(10): 825-31, 2014.
Article
em Ja
| MEDLINE
| ID: mdl-25672209
ABSTRACT
Although brain monoamines serotonin, noradrenaline, and dopamine have been repeatedly shown to be linked to depression, it remains unclear how monoamine dysfunction is mechanistically related to symptoms of depression. We hypothesized that imbalances in the networks of regions innervated by monoamines disrupt patients' learning and decision-making abilities, and this disruption could, in turn, lead to symptoms of depression. We have conducted functional magnetic resonance imaging (fMRI) studies on learning and decision-making, mainly focusing on the role of serotonin. Our results suggest that parallel organization for reward prediction at different time scales in the striatum is under differential modulation by serotonin, and that depression is associated with a diminished recruitment of the dorsal striatum, involved in long-term reward prediction. Based on these findings, the brain mechanisms of depression are discussed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Imageamento por Ressonância Magnética
/
Depressão
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
Ja
Revista:
Seishin Shinkeigaku Zasshi
Assunto da revista:
NEUROLOGIA
/
PSIQUIATRIA
Ano de publicação:
2014
Tipo de documento:
Article