Slingshot-Cofilin activation mediates mitochondrial and synaptic dysfunction via Aß ligation to ß1-integrin conformers.

Woo, J A; Zhao, X; Khan, H; Penn, C; Wang, X; Joly-Amado, A; Weeber, E; Morgan, D; Kang, D E

Woo, J A; Zhao, X; Khan, H; Penn, C; Wang, X; Joly-Amado, A; Weeber, E; Morgan, D; Kang, D E.

Afiliação

Woo JA; 1] Department of Molecular Medicine, University of South Florida Morsani College of Medicine, Tampa, FL, USA [2] USF Health Byrd Alzheimer's Institute, University of South Florida Morsani College of Medicine, Tampa, FL, USA.
Zhao X; 1] Department of Molecular Medicine, University of South Florida Morsani College of Medicine, Tampa, FL, USA [2] USF Health Byrd Alzheimer's Institute, University of South Florida Morsani College of Medicine, Tampa, FL, USA.
Khan H; USF Health Byrd Alzheimer's Institute, University of South Florida Morsani College of Medicine, Tampa, FL, USA.
Penn C; USF Health Byrd Alzheimer's Institute, University of South Florida Morsani College of Medicine, Tampa, FL, USA.
Wang X; 1] USF Health Byrd Alzheimer's Institute, University of South Florida Morsani College of Medicine, Tampa, FL, USA [2] Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine, Tampa, FL, USA.
Joly-Amado A; 1] USF Health Byrd Alzheimer's Institute, University of South Florida Morsani College of Medicine, Tampa, FL, USA [2] Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine, Tampa, FL, USA.
Weeber E; 1] USF Health Byrd Alzheimer's Institute, University of South Florida Morsani College of Medicine, Tampa, FL, USA [2] Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine, Tampa, FL, USA.
Morgan D; 1] USF Health Byrd Alzheimer's Institute, University of South Florida Morsani College of Medicine, Tampa, FL, USA [2] Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine, Tampa, FL, USA.
Kang DE; 1] Department of Molecular Medicine, University of South Florida Morsani College of Medicine, Tampa, FL, USA [2] USF Health Byrd Alzheimer's Institute, University of South Florida Morsani College of Medicine, Tampa, FL, USA.

Cell Death Differ ; 22(6): 921-34, 2015 Jun.

Article em En | MEDLINE | ID: mdl-25698445

Assuntos

Fatores de Despolimerização de Actina/metabolismo; Peptídeos beta-Amiloides/metabolismo; Integrina beta1/metabolismo; Mitocôndrias/metabolismo; Fosfoproteínas Fosfatases/metabolismo; Sinapses/metabolismo; Fatores de Despolimerização de Actina/genética; Animais; Apoptose; Células CHO; Linhagem Celular; Cricetulus; Eletrofisiologia; Hipocampo/metabolismo; Humanos; Immunoblotting; Integrina beta1/genética; Camundongos; Fosfoproteínas Fosfatases/genética; Ligação Proteica; Espécies Reativas de Oxigênio/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sinapses / Peptídeos beta-Amiloides / Fosfoproteínas Fosfatases / Integrina beta1 / Fatores de Despolimerização de Actina / Mitocôndrias Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Cell Death Differ Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos

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