Triggering receptor expressed on myeloid cells 2 (TREM2) deficiency attenuates phagocytic activities of microglia and exacerbates ischemic damage in experimental stroke.

Kawabori, Masahito; Kacimi, Rachid; Kauppinen, Tiina; Calosing, Cyrus; Kim, Jong Youl; Hsieh, Christine L; Nakamura, Mary C; Yenari, Midori A

Kawabori, Masahito; Kacimi, Rachid; Kauppinen, Tiina; Calosing, Cyrus; Kim, Jong Youl; Hsieh, Christine L; Nakamura, Mary C; Yenari, Midori A.

Afiliação

Kawabori M; Departments of Neurology and Medicine, University of California, San Francisco, and.
Kacimi R; Departments of Neurology and Medicine, University of California, San Francisco, and San Francisco Veterans Affairs Medical Center, San Francisco, California 94121, and.
Kauppinen T; Kleysen Institute for Advanced Medicine, Winnipeg, Manitoba R3E 0Z3, Canada.
Calosing C; Departments of Neurology and Medicine, University of California, San Francisco, and.
Kim JY; Departments of Neurology and Medicine, University of California, San Francisco, and.
Hsieh CL; Departments of Neurology and Medicine, University of California, San Francisco, and San Francisco Veterans Affairs Medical Center, San Francisco, California 94121, and.
Nakamura MC; Departments of Neurology and Medicine, University of California, San Francisco, and.
Yenari MA; Departments of Neurology and Medicine, University of California, San Francisco, and San Francisco Veterans Affairs Medical Center, San Francisco, California 94121, and yenari@alum.mit.edu.

J Neurosci ; 35(8): 3384-96, 2015 Feb 25.

Article em En | MEDLINE | ID: mdl-25716838

Assuntos

Infarto da Artéria Cerebral Média/metabolismo; Glicoproteínas de Membrana/metabolismo; Microglia/metabolismo; Fagocitose; Receptores Imunológicos/metabolismo; Animais; Hipóxia Celular; Células Cultivadas; Células Espumosas/metabolismo; Células Espumosas/patologia; Infarto da Artéria Cerebral Média/patologia; Glicoproteínas de Membrana/deficiência; Glicoproteínas de Membrana/genética; Camundongos; Camundongos Endogâmicos C57BL; Microglia/fisiologia; Neurônios/metabolismo; Neurônios/patologia; Receptores Imunológicos/deficiência; Receptores Imunológicos/genética

Palavras-chave

ischemia; neuroprotection; permanent ischemia; phagocytosis; stroke; triggering receptor expressed on myeloid cells-2

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fagocitose / Glicoproteínas de Membrana / Receptores Imunológicos / Microglia / Infarto da Artéria Cerebral Média Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Neurosci Ano de publicação: 2015 Tipo de documento: Article

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