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Cognitive rehabilitation group intervention for breast cancer survivors: results of a randomized clinical trial.
Ercoli, L M; Petersen, L; Hunter, A M; Castellon, S A; Kwan, L; Kahn-Mills, B A; Embree, L M; Cernin, P A; Leuchter, A F; Ganz, P A.
Afiliação
  • Ercoli LM; UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA.
  • Petersen L; UCLA David Geffen School of Medicine, Los Angeles, CA, USA.
  • Hunter AM; Jonsson Comprehensive Cancer Center, Los Angeles, CA, USA.
  • Castellon SA; UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA.
  • Kwan L; UCLA David Geffen School of Medicine, Los Angeles, CA, USA.
  • Kahn-Mills BA; UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA.
  • Embree LM; UCLA David Geffen School of Medicine, Los Angeles, CA, USA.
  • Cernin PA; Veteran's Administration Greater Los Angeles Healthcare System, Los Angeles, CA, USA.
  • Leuchter AF; UCLA David Geffen School of Medicine, Los Angeles, CA, USA.
  • Ganz PA; Jonsson Comprehensive Cancer Center, Los Angeles, CA, USA.
Psychooncology ; 24(11): 1360-7, 2015 Nov.
Article em En | MEDLINE | ID: mdl-25759235
PURPOSE: We conducted a randomized clinical trial evaluating the efficacy of a cognitive rehabilitation (CR) intervention compared with a wait list (WL) control condition on cognitive complaints, neuropsychological and brain functioning in breast cancer survivors (BCS). METHODS: The small group intervention of five sessions included psychoeducation and cognitive exercises. ELIGIBILITY: Disease-free BCS with cognitive complaints, diagnosed with stage I, II or III breast cancer, completed primary treatment 18 months to 5 years earlier. Neurocognitive test data and cognitive complaints on the Patient's Assessment of Own Functioning Inventory (PAOFI) were assessed at baseline (T1), immediately post-intervention (T2), and 2 months later (T3). A subgroup of participants underwent resting state quantitative electroencephalography (qEEG) at all three assessment time points. RESULTS: Forty-eight participants [mean age (SD) 53.8 (8.2)] completed T1 assessments, and 29 participants had analyzable qEEG data. The CR group improved significantly over time compared with the WL group on PAOFI total and memory scores (both p = .01) and on Rey Auditory Verbal Learning Test (RAVLT) total (trials I-V) (p = .02) and RAVLT delayed recall (p = .007) scores. On qEEG, the CR group showed a significant decrease in delta 'slow wave' power (p = .02) and an increase in the frontal distribution of alpha power (p = .04) from T1 to T2. CONCLUSIONS: BCS in the CR group showed immediate and sustained improvements in self-reported cognitive complaints and memory functioning on neurocognitive testing. Results of the qEEG substudy provide some support for neurophysiological changes underlying the intervention. Copyright © 2015 John Wiley & Sons, Ltd.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Psicoterapia de Grupo / Neoplasias da Mama / Terapia Cognitivo-Comportamental / Sobreviventes / Disfunção Cognitiva Tipo de estudo: Clinical_trials Limite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Psychooncology Assunto da revista: NEOPLASIAS / PSICOLOGIA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Psicoterapia de Grupo / Neoplasias da Mama / Terapia Cognitivo-Comportamental / Sobreviventes / Disfunção Cognitiva Tipo de estudo: Clinical_trials Limite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Psychooncology Assunto da revista: NEOPLASIAS / PSICOLOGIA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos