A child with Li-Fraumeni syndrome: Modes to inactivate the second allele of TP53 in three different malignancies.

Schlegelberger, Brigitte; Kreipe, Hans; Lehmann, Ulrich; Steinemann, Doris; Ripperger, Tim; Göhring, Gudrun; Thomay, Kathrin; Rump, Andreas; Di Donato, Nataliya; Suttorp, Meinolf

Schlegelberger, Brigitte; Kreipe, Hans; Lehmann, Ulrich; Steinemann, Doris; Ripperger, Tim; Göhring, Gudrun; Thomay, Kathrin; Rump, Andreas; Di Donato, Nataliya; Suttorp, Meinolf.

Afiliação

Schlegelberger B; Institute of Human Genetics, Hannover Medical School, Hannover, Germany.
Kreipe H; Institute of Pathology, Hannover Medical School, Hannover, Germany.
Lehmann U; Institute of Pathology, Hannover Medical School, Hannover, Germany.
Steinemann D; Institute of Human Genetics, Hannover Medical School, Hannover, Germany.
Ripperger T; Institute of Human Genetics, Hannover Medical School, Hannover, Germany.
Göhring G; Institute of Human Genetics, Hannover Medical School, Hannover, Germany.
Thomay K; Institute of Human Genetics, Hannover Medical School, Hannover, Germany.
Rump A; Institute for Clinical Genetics, Medical Faculty Carl Gustav Carus, TU Dresden, Germany.
Di Donato N; Institute for Clinical Genetics, Medical Faculty Carl Gustav Carus, TU Dresden, Germany.
Suttorp M; Department of Pediatric Hematology and Oncology, University Hospital Dresden, Germany.

Pediatr Blood Cancer ; 62(8): 1481-4, 2015 Aug.

Article em En | MEDLINE | ID: mdl-25787918

Assuntos

Carcinoma/genética; Neoplasias do Plexo Corióideo/genética; Leucemia Mieloide Aguda/genética; Síndrome de Li-Fraumeni/genética; Proteína Supressora de Tumor p53/genética; Tumor de Wilms/genética; Sequência de Bases; Transformação Celular Neoplásica/genética; Criança; Feminino; Inativação Gênica; Humanos; Síndrome de Li-Fraumeni/terapia; Mutação; Análise de Sequência de DNA

Palavras-chave

Li-Fraumeni syndrome; TP53; choroid plexus carcinoma; leukemia; sarcoma; uniparental disomy (UPD)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma / Leucemia Mieloide Aguda / Proteína Supressora de Tumor p53 / Síndrome de Li-Fraumeni / Neoplasias do Plexo Corióideo / Tumor de Wilms Limite: Child / Female / Humans Idioma: En Revista: Pediatr Blood Cancer Assunto da revista: HEMATOLOGIA / NEOPLASIAS / PEDIATRIA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Alemanha

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