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The brown fat secretome: metabolic functions beyond thermogenesis.
Wang, Guo-Xiao; Zhao, Xu-Yun; Lin, Jiandie D.
Afiliação
  • Wang GX; Life Sciences Institute and Department of Cell & Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109, USA.
  • Zhao XY; Life Sciences Institute and Department of Cell & Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109, USA.
  • Lin JD; Life Sciences Institute and Department of Cell & Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109, USA. Electronic address: jdlin@umich.edu.
Trends Endocrinol Metab ; 26(5): 231-7, 2015 May.
Article em En | MEDLINE | ID: mdl-25843910
ABSTRACT
Brown fat is highly active in fuel oxidation and dissipates chemical energy through uncoupling protein (UCP)1-mediated heat production. Activation of brown fat leads to increased energy expenditure, reduced adiposity, and lower plasma glucose and lipid levels, thus contributing to better homeostasis. Uncoupled respiration and thermogenesis have been considered to be responsible for the metabolic benefits of brown adipose tissue. Recent studies have demonstrated that brown adipocytes also secrete factors that act locally and systemically to influence fuel and energy metabolism. This review discusses the evidence supporting a thermogenesis-independent role of brown fat, particularly through its release of secreted factors, and their implications in physiology and therapeutic development.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tecido Adiposo Marrom / Termogênese Limite: Animals / Humans Idioma: En Revista: Trends Endocrinol Metab Assunto da revista: ENDOCRINOLOGIA / METABOLISMO Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tecido Adiposo Marrom / Termogênese Limite: Animals / Humans Idioma: En Revista: Trends Endocrinol Metab Assunto da revista: ENDOCRINOLOGIA / METABOLISMO Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos