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Discovering anti-platelet drug combinations with an integrated model of activator-inhibitor relationships, activator-activator synergies and inhibitor-inhibitor synergies.
Lombardi, Federica; Golla, Kalyan; Fitzpatrick, Darren J; Casey, Fergal P; Moran, Niamh; Shields, Denis C.
Afiliação
  • Lombardi F; Complex and Adaptive Systems Laboratory, University College Dublin, Dublin, Ireland; Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland; Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland; School of Medicine an
  • Golla K; Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland.
  • Fitzpatrick DJ; Complex and Adaptive Systems Laboratory, University College Dublin, Dublin, Ireland; Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland; School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland.
  • Casey FP; Complex and Adaptive Systems Laboratory, University College Dublin, Dublin, Ireland; Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland; School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland.
  • Moran N; Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland.
  • Shields DC; Complex and Adaptive Systems Laboratory, University College Dublin, Dublin, Ireland; Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland; School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland.
PLoS Comput Biol ; 11(4): e1004119, 2015 Apr.
Article em En | MEDLINE | ID: mdl-25875950
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plaquetas / Inibidores da Agregação Plaquetária / Ativação Plaquetária / Modelos Estatísticos / Descoberta de Drogas Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: PLoS Comput Biol Assunto da revista: BIOLOGIA / INFORMATICA MEDICA Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plaquetas / Inibidores da Agregação Plaquetária / Ativação Plaquetária / Modelos Estatísticos / Descoberta de Drogas Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: PLoS Comput Biol Assunto da revista: BIOLOGIA / INFORMATICA MEDICA Ano de publicação: 2015 Tipo de documento: Article