Sequential cancer mutations in cultured human intestinal stem cells.

Drost, Jarno; van Jaarsveld, Richard H; Ponsioen, Bas; Zimberlin, Cheryl; van Boxtel, Ruben; Buijs, Arjan; Sachs, Norman; Overmeer, René M; Offerhaus, G Johan; Begthel, Harry; Korving, Jeroen; van de Wetering, Marc; Schwank, Gerald; Logtenberg, Meike; Cuppen, Edwin; Snippert, Hugo J; Medema, Jan Paul; Kops, Geert J P L; Clevers, Hans

Drost, Jarno; van Jaarsveld, Richard H; Ponsioen, Bas; Zimberlin, Cheryl; van Boxtel, Ruben; Buijs, Arjan; Sachs, Norman; Overmeer, René M; Offerhaus, G Johan; Begthel, Harry; Korving, Jeroen; van de Wetering, Marc; Schwank, Gerald; Logtenberg, Meike; Cuppen, Edwin; Snippert, Hugo J; Medema, Jan Paul; Kops, Geert J P L; Clevers, Hans.

Afiliação

Drost J; 1] Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and UMC Utrecht, 3584CT Utrecht, The Netherlands [2] Cancer Genomics Netherlands, UMC Utrecht, 3584CG Utrecht, The Netherlands.
van Jaarsveld RH; 1] Cancer Genomics Netherlands, UMC Utrecht, 3584CG Utrecht, The Netherlands [2] Molecular Cancer Research, Centre for Molecular Medicine, UMC Utrecht, 3584CG, Utrecht, The Netherlands.
Ponsioen B; 1] Cancer Genomics Netherlands, UMC Utrecht, 3584CG Utrecht, The Netherlands [2] Molecular Cancer Research, Centre for Molecular Medicine, UMC Utrecht, 3584CG, Utrecht, The Netherlands.
Zimberlin C; 1] Cancer Genomics Netherlands, UMC Utrecht, 3584CG Utrecht, The Netherlands [2] Laboratory of Experimental Oncology and Radiobiology, Centre for Experimental Molecular Medicine, AMC, 1105AZ Amsterdam, The Netherlands.
van Boxtel R; 1] Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and UMC Utrecht, 3584CT Utrecht, The Netherlands [2] Cancer Genomics Netherlands, UMC Utrecht, 3584CG Utrecht, The Netherlands.
Buijs A; Department of Medical Genetics, UMC Utrecht, 3508AB Utrecht, The Netherlands.
Sachs N; 1] Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and UMC Utrecht, 3584CT Utrecht, The Netherlands [2] Cancer Genomics Netherlands, UMC Utrecht, 3584CG Utrecht, The Netherlands.
Overmeer RM; 1] Cancer Genomics Netherlands, UMC Utrecht, 3584CG Utrecht, The Netherlands [2] Molecular Cancer Research, Centre for Molecular Medicine, UMC Utrecht, 3584CG, Utrecht, The Netherlands.
Offerhaus GJ; Department of Pathology, UMC Utrecht, 3584CX Utrecht, The Netherlands.
Begthel H; 1] Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and UMC Utrecht, 3584CT Utrecht, The Netherlands [2] Cancer Genomics Netherlands, UMC Utrecht, 3584CG Utrecht, The Netherlands.
Korving J; 1] Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and UMC Utrecht, 3584CT Utrecht, The Netherlands [2] Cancer Genomics Netherlands, UMC Utrecht, 3584CG Utrecht, The Netherlands.
van de Wetering M; 1] Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and UMC Utrecht, 3584CT Utrecht, The Netherlands [2] Cancer Genomics Netherlands, UMC Utrecht, 3584CG Utrecht, The Netherlands [3] Foundation Hubrecht Organoid Technology (HUB), 3584CT Utrecht, The Netherlands.
Schwank G; 1] Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and UMC Utrecht, 3584CT Utrecht, The Netherlands [2] Cancer Genomics Netherlands, UMC Utrecht, 3584CG Utrecht, The Netherlands.
Logtenberg M; 1] Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and UMC Utrecht, 3584CT Utrecht, The Netherlands [2] Cancer Genomics Netherlands, UMC Utrecht, 3584CG Utrecht, The Netherlands.
Cuppen E; 1] Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and UMC Utrecht, 3584CT Utrecht, The Netherlands [2] Cancer Genomics Netherlands, UMC Utrecht, 3584CG Utrecht, The Netherlands.
Snippert HJ; 1] Cancer Genomics Netherlands, UMC Utrecht, 3584CG Utrecht, The Netherlands [2] Molecular Cancer Research, Centre for Molecular Medicine, UMC Utrecht, 3584CG, Utrecht, The Netherlands.
Medema JP; 1] Cancer Genomics Netherlands, UMC Utrecht, 3584CG Utrecht, The Netherlands [2] Laboratory of Experimental Oncology and Radiobiology, Centre for Experimental Molecular Medicine, AMC, 1105AZ Amsterdam, The Netherlands.
Kops GJ; 1] Cancer Genomics Netherlands, UMC Utrecht, 3584CG Utrecht, The Netherlands [2] Molecular Cancer Research, Centre for Molecular Medicine, UMC Utrecht, 3584CG, Utrecht, The Netherlands.
Clevers H; 1] Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and UMC Utrecht, 3584CT Utrecht, The Netherlands [2] Cancer Genomics Netherlands, UMC Utrecht, 3584CG Utrecht, The Netherlands.

Nature ; 521(7550): 43-7, 2015 May 07.

Article em En | MEDLINE | ID: mdl-25924068

Assuntos

Neoplasias Colorretais/genética; Neoplasias Colorretais/patologia; Intestinos/patologia; Mutação/genética; Organoides/metabolismo; Organoides/patologia; Células-Tronco/patologia; Aneuploidia; Animais; Sistemas CRISPR-Cas; Criança; Pré-Escolar; Neoplasias Colorretais/metabolismo; Feminino; Genes APC; Genes p53/genética; Xenoenxertos; Humanos; Imidazóis; Peptídeos e Proteínas de Sinalização Intercelular/metabolismo; Mucosa Intestinal/metabolismo; Camundongos; Pessoa de Meia-Idade; Mutagênese Sítio-Dirigida; Invasividade Neoplásica/genética; Invasividade Neoplásica/patologia; Transplante de Neoplasias; Piperazinas; Proteínas Proto-Oncogênicas p21(ras)/genética; Proteínas Proto-Oncogênicas p21(ras)/metabolismo; Proteína Smad4/deficiência; Nicho de Células-Tronco/fisiologia; Células-Tronco/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco / Neoplasias Colorretais / Organoides / Intestinos / Mutação Limite: Animals / Child / Child, preschool / Female / Humans / Middle aged Idioma: En Revista: Nature Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Holanda

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