Functional characterization of RAD52 as a lung cancer susceptibility gene in the 12p13.33 locus.

Lieberman, Rachel; Xiong, Donghai; James, Michael; Han, Younghun; Amos, Christopher I; Wang, Liang; You, Ming

Lieberman, Rachel; Xiong, Donghai; James, Michael; Han, Younghun; Amos, Christopher I; Wang, Liang; You, Ming.

Afiliação

Lieberman R; Department of Pharmacology & Toxicology and Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin.
Xiong D; Department of Pharmacology & Toxicology and Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin.
James M; Department of Pharmacology & Toxicology and Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin.
Han Y; Department of Community and Family Medicine, Geisel School of Medicine, Dartmouth College, Lebanon, New Hampshire.
Amos CI; Department of Community and Family Medicine, Geisel School of Medicine, Dartmouth College, Lebanon, New Hampshire.
Wang L; Department of Pathology and Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin.
You M; Department of Pharmacology & Toxicology and Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin.

Mol Carcinog ; 55(5): 953-63, 2016 May.

Article em En | MEDLINE | ID: mdl-26013599

Assuntos

Carcinoma de Células Escamosas/genética; Cromossomos Humanos Par 12/genética; Neoplasias Pulmonares/genética; Proteína Rad52 de Recombinação e Reparo de DNA/genética; Proteína Rad52 de Recombinação e Reparo de DNA/metabolismo; Animais; Linhagem Celular Tumoral; Proliferação de Células; Dano ao DNA; Amplificação de Genes; Predisposição Genética para Doença; Humanos; Camundongos; Transplante de Neoplasias; Polimorfismo de Nucleotídeo Único; Locos de Características Quantitativas; População Branca/genética

Palavras-chave

DNA damage; cancer susceptibility gene; eQTL; gene amplification; lung cancer; non-small cell lung carcinoma; senescence

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cromossomos Humanos Par 12 / Carcinoma de Células Escamosas / Proteína Rad52 de Recombinação e Reparo de DNA / Neoplasias Pulmonares Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Mol Carcinog Assunto da revista: BIOLOGIA MOLECULAR / NEOPLASIAS Ano de publicação: 2016 Tipo de documento: Article

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