Phase 1 dose de-escalation trial of the endogenous folate [6R]-5,10-methylene tetrahydrofolate in combination with fixed-dose pemetrexed as neoadjuvant therapy in patients with resectable rectal cancer.

Gustavsson, Bengt; Carlsson, Göran; Swartling, Torbjörn; Kurlberg, Göran; Derwinger, Kristoffer; Björkqvist, Hillevi; Odin, Elisabeth; Gibson, Fernando

Gustavsson, Bengt; Carlsson, Göran; Swartling, Torbjörn; Kurlberg, Göran; Derwinger, Kristoffer; Björkqvist, Hillevi; Odin, Elisabeth; Gibson, Fernando.

Afiliação

Gustavsson B; Department of Surgery, University of Gothenburg, Sahlgrenska University Hospital/Östra Institute of Clinical Sciences, Gothenburg, Sweden.
Carlsson G; Department of Surgery, University of Gothenburg, Sahlgrenska University Hospital/Östra Institute of Clinical Sciences, Gothenburg, Sweden.
Swartling T; Department of Surgery, University of Gothenburg, Sahlgrenska University Hospital/Östra Institute of Clinical Sciences, Gothenburg, Sweden.
Kurlberg G; Department of Surgery, University of Gothenburg, Sahlgrenska University Hospital/Östra Institute of Clinical Sciences, Gothenburg, Sweden.
Derwinger K; Department of Surgery, University of Gothenburg, Sahlgrenska University Hospital/Östra Institute of Clinical Sciences, Gothenburg, Sweden.
Björkqvist H; Department of Surgery, University of Gothenburg, Sahlgrenska University Hospital/Östra Institute of Clinical Sciences, Gothenburg, Sweden.
Odin E; Department of Surgery, University of Gothenburg, Sahlgrenska University Hospital/Östra Institute of Clinical Sciences, Gothenburg, Sweden.
Gibson F; PharmaGenesis London, 9 Whitehall, 4th Floor, London, SW1A 2DD, UK. fernando.gibson@pharmagenesis.com.

Invest New Drugs ; 33(5): 1078-85, 2015 Oct.

Article em En | MEDLINE | ID: mdl-26189513

Assuntos

Adenocarcinoma/tratamento farmacológico; Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico; Terapia Neoadjuvante; Neoplasias Retais/tratamento farmacológico; Adenocarcinoma/cirurgia; Idoso; Protocolos de Quimioterapia Combinada Antineoplásica/administração & dosagem; Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos; Relação Dose-Resposta a Droga; Esquema de Medicação; Feminino; Humanos; Masculino; Pessoa de Meia-Idade; Pemetrexede/uso terapêutico; Neoplasias Retais/cirurgia; Tetra-Hidrofolatos/uso terapêutico

Palavras-chave

Antifolates; Endogenous folate; Neoadjuvant therapy; Pemetrexed; Phase 1 trial; Rectal cancer; [6R]-5,10-methylene tetrahydrofolate

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Retais / Adenocarcinoma / Protocolos de Quimioterapia Combinada Antineoplásica / Terapia Neoadjuvante Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Invest New Drugs Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Suécia

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google