Physical exercise for late-life major depression.
Br J Psychiatry
; 207(3): 235-42, 2015 Sep.
Article
em En
| MEDLINE
| ID: mdl-26206864
ABSTRACT
BACKGROUND:
Interventions including physical exercise may help improve the outcomes of late-life major depression, but few studies are available.AIMS:
To investigate whether augmenting sertraline therapy with physical exercise leads to better outcomes of late-life major depression.METHOD:
Primary care patients (465 years) with major depression were randomised to 24 weeks of higher-intensity, progressive aerobic exercise plus sertraline (S+PAE), lower-intensity, non-progressive exercise plus sertraline (S+NPE) and sertraline alone. The primary outcome was remission (a score of ≤10 on the Hamilton Rating Scale for Depression).RESULTS:
A total of 121 patients were included. At study end, 45% of participants in the sertraline group, 73% of those in the S+NPE group and 81% of those in the S+PAE group achieved remission (P = 0.001). A shorter time to remission was observed in the S+PAE group than in the sertraline-only group.CONCLUSIONS:
Physical exercise may be a safe and effective augmentation to antidepressant therapy in late-life major depression.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transtorno Depressivo Maior
/
Terapia por Exercício
Tipo de estudo:
Clinical_trials
Limite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Br J Psychiatry
Ano de publicação:
2015
Tipo de documento:
Article