Propranolol Decreases Proliferation of Endothelial Cells Transformed by Kaposi's Sarcoma-Associated Herpesvirus and Induces Lytic Viral Gene Expression.
J Virol
; 89(21): 11144-9, 2015 Nov.
Article
em En
| MEDLINE
| ID: mdl-26269192
ABSTRACT
Kaposi's sarcoma (KS) is common in Africa, but economic constraints hinder successful treatment in most patients. Propranolol, a generic ß-adrenergic antagonist, decreased proliferation of KS-associated herpesvirus (KSHV)-infected cells. Downregulation of cyclin A2 and cyclin-dependent kinase 1 (CDK1) recapitulated this phenotype. Additionally, propranolol induced lytic gene expression in association with downregulation of CDK6. Thus, propranolol has diverse effects on KSHV-infected cells, and this generic drug has potential as a therapeutic agent for KS.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Propranolol
/
Sarcoma de Kaposi
/
Regulação Neoplásica da Expressão Gênica
/
Antagonistas Adrenérgicos beta
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Herpesvirus Humano 8
/
Células Endoteliais
/
Proliferação de Células
Tipo de estudo:
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
J Virol
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Estados Unidos