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A Conserved Bicycle Model for Circadian Clock Control of Membrane Excitability.
Flourakis, Matthieu; Kula-Eversole, Elzbieta; Hutchison, Alan L; Han, Tae Hee; Aranda, Kimberly; Moose, Devon L; White, Kevin P; Dinner, Aaron R; Lear, Bridget C; Ren, Dejian; Diekman, Casey O; Raman, Indira M; Allada, Ravi.
Afiliação
  • Flourakis M; Department of Neurobiology, Northwestern University, Evanston, IL 60208, USA.
  • Kula-Eversole E; Department of Neurobiology, Northwestern University, Evanston, IL 60208, USA.
  • Hutchison AL; Medical Scientist Training Program, James Franck Institute, Department of Chemistry, Institute for Biophysical Dynamics, University of Chicago, Chicago, IL 60637, USA.
  • Han TH; Department of Neurobiology, Northwestern University, Evanston, IL 60208, USA.
  • Aranda K; Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Moose DL; Department of Biology, University of Iowa, Iowa City, IA 52242, USA.
  • White KP; Institute for Genomics and Systems Biology, University of Chicago, Chicago, IL 60637, USA.
  • Dinner AR; Medical Scientist Training Program, James Franck Institute, Department of Chemistry, Institute for Biophysical Dynamics, University of Chicago, Chicago, IL 60637, USA.
  • Lear BC; Department of Biology, University of Iowa, Iowa City, IA 52242, USA.
  • Ren D; Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Diekman CO; Department of Mathematical Sciences, New Jersey Institute of Technology, Newark, NJ 07102, USA.
  • Raman IM; Department of Neurobiology, Northwestern University, Evanston, IL 60208, USA.
  • Allada R; Department of Neurobiology, Northwestern University, Evanston, IL 60208, USA. Electronic address: r-allada@northwestern.edu.
Cell ; 162(4): 836-48, 2015 Aug 13.
Article em En | MEDLINE | ID: mdl-26276633
Circadian clocks regulate membrane excitability in master pacemaker neurons to control daily rhythms of sleep and wake. Here, we find that two distinctly timed electrical drives collaborate to impose rhythmicity on Drosophila clock neurons. In the morning, a voltage-independent sodium conductance via the NA/NALCN ion channel depolarizes these neurons. This current is driven by the rhythmic expression of NCA localization factor-1, linking the molecular clock to ion channel function. In the evening, basal potassium currents peak to silence clock neurons. Remarkably, daily antiphase cycles of sodium and potassium currents also drive mouse clock neuron rhythms. Thus, we reveal an evolutionarily ancient strategy for the neural mechanisms that govern daily sleep and wake.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ritmo Circadiano / Drosophila / Relógios Circadianos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Cell Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ritmo Circadiano / Drosophila / Relógios Circadianos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Cell Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos