Your browser doesn't support javascript.
loading
Cold Exposure Partially Corrects Disturbances in Lipid Metabolism in a Male Mouse Model of Glucocorticoid Excess.
van den Beukel, Johanna C; Boon, Mariëtte R; Steenbergen, Jacobie; Rensen, Patrick C N; Meijer, Onno C; Themmen, Axel P N; Grefhorst, Aldo.
Afiliação
  • van den Beukel JC; Department of Internal Medicine (J.C.v.d.B., J.S., A.P.N.T., A.G.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Medicine (M.R.B., P.C.N.R., O.C.M.), Division of Endocrinology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands; and Einthoven La
  • Boon MR; Department of Internal Medicine (J.C.v.d.B., J.S., A.P.N.T., A.G.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Medicine (M.R.B., P.C.N.R., O.C.M.), Division of Endocrinology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands; and Einthoven La
  • Steenbergen J; Department of Internal Medicine (J.C.v.d.B., J.S., A.P.N.T., A.G.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Medicine (M.R.B., P.C.N.R., O.C.M.), Division of Endocrinology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands; and Einthoven La
  • Rensen PC; Department of Internal Medicine (J.C.v.d.B., J.S., A.P.N.T., A.G.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Medicine (M.R.B., P.C.N.R., O.C.M.), Division of Endocrinology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands; and Einthoven La
  • Meijer OC; Department of Internal Medicine (J.C.v.d.B., J.S., A.P.N.T., A.G.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Medicine (M.R.B., P.C.N.R., O.C.M.), Division of Endocrinology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands; and Einthoven La
  • Themmen AP; Department of Internal Medicine (J.C.v.d.B., J.S., A.P.N.T., A.G.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Medicine (M.R.B., P.C.N.R., O.C.M.), Division of Endocrinology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands; and Einthoven La
  • Grefhorst A; Department of Internal Medicine (J.C.v.d.B., J.S., A.P.N.T., A.G.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Medicine (M.R.B., P.C.N.R., O.C.M.), Division of Endocrinology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands; and Einthoven La
Endocrinology ; 156(11): 4115-28, 2015 Nov.
Article em En | MEDLINE | ID: mdl-26372178
High glucocorticoid concentrations are accompanied by metabolic side effects such as high plasma triglyceride (TG) concentrations. Liver, brown adipose tissue (BAT) and white adipose tissue are important regulators of plasma TG. Exposure to 4°C reduces plasma TG concentrations, and we therefore aimed to study the interaction between glucocorticoid excess and 24 hours of exposure to 4°C on lipid metabolism. For this, mice were implanted with 50-mg corticosterone or control pellets and housed for 24 hours at 23°C or 4°C 1 week later, after which various aspects of TG metabolism in liver, BAT, and white adipose tissue were studied. Corticosterone treatment resulted in a 3.8-fold increase of plasma TG concentrations. Increased TG was normalized by cold exposure, an effect still present 24 hours after cold exposure. Corticosterone treatment increased hepatic TG content by 3.5-fold and provoked secretion of large, TG-rich very low density lipoprotein particles. Cold exposure reduced very low density lipoprotein-TG secretion by approximately 50%. Corticosterone strongly decreased BAT activity: BAT weight increased by 3.5-fold, whereas uncoupling protein 1 (Ucp1) mRNA expression and Ucp1 protein content of BAT were reduced by 75% and 60%, respectively. Cold exposure partially normalized these parameters of BAT activity. The uptake of TG by BAT was not affected by corticosterone treatment but was increased 4.5-fold upon cold exposure. In conclusion, cold exposure normalizes corticosterone-induced hypertriglyceridemia, at least partly via activating BAT.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tecido Adiposo Marrom / Corticosterona / Temperatura Baixa / Metabolismo dos Lipídeos / Tecido Adiposo Branco / Glucocorticoides Limite: Animals Idioma: En Revista: Endocrinology Ano de publicação: 2015 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tecido Adiposo Marrom / Corticosterona / Temperatura Baixa / Metabolismo dos Lipídeos / Tecido Adiposo Branco / Glucocorticoides Limite: Animals Idioma: En Revista: Endocrinology Ano de publicação: 2015 Tipo de documento: Article