Utility of Oral Swab Sampling for Ebola Virus Detection in Guinea Pig Model.

Spengler, Jessica R; Chakrabarti, Ayan K; Coleman-McCray, JoAnn D; Martin, Brock E; Nichol, Stuart T; Spiropoulou, Christina F; Bird, Brian H

Spengler, Jessica R; Chakrabarti, Ayan K; Coleman-McCray, JoAnn D; Martin, Brock E; Nichol, Stuart T; Spiropoulou, Christina F; Bird, Brian H.

Emerg Infect Dis ; 21(10): 1816-9, 2015 Oct.

Article em En | MEDLINE | ID: mdl-26401603

ABSTRACT

ABSTRACT

To determine the utility of oral swabs for diagnosing infection with Ebola virus, we used a guinea pig model and obtained daily antemortem and postmortem swab samples. According to quantitative reverse transcription PCR analysis, the diagnostic value was poor for antemortem swab samples but excellent for postmortem samples.

Assuntos

Diagnóstico Precoce; Ebolavirus; Doença pelo Vírus Ebola/diagnóstico; Boca/virologia; Manejo de Espécimes/métodos; Animais; Cobaias; Doença pelo Vírus Ebola/virologia; Humanos

Palavras-chave

Ebola; guinea pig; oral swab; qRT-PCR; viral hemorrhagic fever; viruses; wild-type Ebola virus

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Manejo de Espécimes / Doença pelo Vírus Ebola / Diagnóstico Precoce / Ebolavirus / Boca Tipo de estudo: Diagnostic_studies / Prognostic_studies / Screening_studies Limite: Animals / Humans Idioma: En Revista: Emerg Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2015 Tipo de documento: Article

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