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Design, synthesis, and biological evaluation of aminopyrazine derivatives as inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2).
Lin, Songnian; Malkani, Sunita; Lombardo, Matthew; Yang, Lihu; Mills, Sander G; Chapman, Kevin; Thompson, James E; Zhang, Wen Xiao; Wang, Ruixiu; Cubbon, Rose M; O'Neill, Edward A; Hale, Jeffrey J.
Afiliação
  • Lin S; Early Development and Discovery Science, Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ 07033, United States. Electronic address: songnian.lin@merck.com.
  • Malkani S; Early Development and Discovery Science, Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ 07033, United States.
  • Lombardo M; Early Development and Discovery Science, Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ 07033, United States.
  • Yang L; Early Development and Discovery Science, Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ 07033, United States.
  • Mills SG; Early Development and Discovery Science, Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ 07033, United States.
  • Chapman K; Early Development and Discovery Science, Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ 07033, United States.
  • Thompson JE; Early Development and Discovery Science, Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ 07033, United States.
  • Zhang WX; Early Development and Discovery Science, Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ 07033, United States.
  • Wang R; Early Development and Discovery Science, Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ 07033, United States.
  • Cubbon RM; Early Development and Discovery Science, Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ 07033, United States.
  • O'Neill EA; Early Development and Discovery Science, Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ 07033, United States.
  • Hale JJ; Early Development and Discovery Science, Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ 07033, United States.
Bioorg Med Chem Lett ; 25(22): 5402-8, 2015 Nov 15.
Article em En | MEDLINE | ID: mdl-26403928
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirazinas / Desenho de Fármacos / Proteína Quinase 1 Ativada por Mitógeno Limite: Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirazinas / Desenho de Fármacos / Proteína Quinase 1 Ativada por Mitógeno Limite: Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2015 Tipo de documento: Article