Humoral Mediators of Remote Ischemic Conditioning: Important Role of eNOS/NO/Nitrite.
Acta Neurochir Suppl
; 121: 45-8, 2016.
Article
em En
| MEDLINE
| ID: mdl-26463921
ABSTRACT
Remote ischemic conditioning (RIC) is a powerful cardioprotectant and neuroprotectant. The mechanism of protection likely involves circulating, blood-borne mediators that transmit the signal from the periphery to the brain. The neuroprotective effect of RIC may be partially related to improvements in cerebral blood flow (CBF). Nitrite is a key circulating mediator of RIC and may be a mediator of increased CBF and also mediate cytoprotection through its effects on nitrosylation of mitochondrial proteins such as complex I. Measuring plasma nitrite may serve as an important blood biomarker, and measuring CBF by techniques such as MRI arterial spin labeling (ASL) may be an ideal surrogate imaging biomarker in clinical trials of RIC.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Isquemia Encefálica
/
Circulação Cerebrovascular
/
Precondicionamento Isquêmico
/
Óxido Nítrico Sintase Tipo III
/
Óxido Nítrico
/
Nitritos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Acta Neurochir Suppl
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Estados Unidos