N-Linked Glycans of Chloroviruses Sharing a Core Architecture without Precedent.
Angew Chem Int Ed Engl
; 55(2): 654-8, 2016 Jan 11.
Article
em En
| MEDLINE
| ID: mdl-26582281
ABSTRACT
N-glycosylation is a fundamental modification of proteins and exists in the three domains of life and in some viruses, including the chloroviruses, for which a new type of core N-glycan is herein described. This N-glycan core structure, common to all chloroviruses, is a pentasaccharide with a ß-glucose linked to an asparagine residue which is not located in the typical sequon N-X-T/S. The glucose is linked to a terminal xylose unit and a hyperbranched fucose, which is in turn substituted with a terminal galactose and a second xylose residue. The third position of the fucose unit is always linked to a rhamnose, which is a semiconserved element because its absolute configuration is virus-dependent. Additional decorations occur on this core N-glycan and represent a molecular signature for each chlorovirus.
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01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polissacarídeos
/
Phycodnaviridae
Idioma:
En
Revista:
Angew Chem Int Ed Engl
Ano de publicação:
2016
Tipo de documento:
Article