Signaling pathway models as biomarkers: Patient-specific simulations of JNK activity predict the survival of neuroblastoma patients.

Fey, Dirk; Halasz, Melinda; Dreidax, Daniel; Kennedy, Sean P; Hastings, Jordan F; Rauch, Nora; Munoz, Amaya Garcia; Pilkington, Ruth; Fischer, Matthias; Westermann, Frank; Kolch, Walter; Kholodenko, Boris N; Croucher, David R

Fey, Dirk; Halasz, Melinda; Dreidax, Daniel; Kennedy, Sean P; Hastings, Jordan F; Rauch, Nora; Munoz, Amaya Garcia; Pilkington, Ruth; Fischer, Matthias; Westermann, Frank; Kolch, Walter; Kholodenko, Boris N; Croucher, David R.

Afiliação

Fey D; Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland.
Halasz M; Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland.
Dreidax D; Department of Neuroblastoma Genomics (B087), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Kennedy SP; Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland.
Hastings JF; The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, New South Wales 2010, Australia.
Rauch N; Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland.
Munoz AG; Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland.
Pilkington R; Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland.
Fischer M; Department of Pediatric Hematology and Oncology, University Hospital Cologne, 50937 Cologne, Germany. Center for Molecular Medicine Cologne, University of Cologne, 50931 Cologne, Germany. Max Planck Institute for Metabolism Research, 50931 Cologne, Germany.
Westermann F; Department of Neuroblastoma Genomics (B087), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Kolch W; Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland. School of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4, Ireland. Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland.
Kholodenko BN; Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland. School of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4, Ireland. Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland. d.crouche
Croucher DR; Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland. The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, New South Wales 2010, Australia. St Vincent's Clinical School, University of New South Wales, Sydney, New South Wales 2052, Australia. d.croucher

Sci Signal ; 8(408): ra130, 2015 Dec 22.

Article em En | MEDLINE | ID: mdl-26696630

Assuntos

Biomarcadores Tumorais/metabolismo; MAP Quinase Quinase 4/metabolismo; Modelos Biológicos; Neuroblastoma/metabolismo; Neuroblastoma/mortalidade; Proteínas Nucleares/metabolismo; Proteínas Oncogênicas/metabolismo; Transdução de Sinais; Adolescente; Animais; Linhagem Celular Tumoral; Criança; Pré-Escolar; Intervalo Livre de Doença; Feminino; Seguimentos; Humanos; Lactente; Masculino; Proteína Proto-Oncogênica N-Myc; Neoplasias Experimentais/metabolismo; Valor Preditivo dos Testes; Taxa de Sobrevida; Peixe-Zebra/metabolismo; Proteínas de Peixe-Zebra/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Nucleares / Transdução de Sinais / Biomarcadores Tumorais / Proteínas Oncogênicas / MAP Quinase Quinase 4 / Modelos Biológicos / Neuroblastoma Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Animals / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Sci Signal Assunto da revista: CIENCIA / FISIOLOGIA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Irlanda

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