MEK/ERK pathway activation by insulin receptor isoform alteration is associated with the abnormal proliferation and differentiation of intestinal epithelial cells in diabetic mice.

Ouyang, Hui; Yang, Hong-Sheng; Yu, Tao; Shan, Ti-Dong; Li, Jie-Yao; Huang, Can-Ze; Zhong, Wa; Xia, Zhong-Sheng; Chen, Qi-Kui

Ouyang, Hui; Yang, Hong-Sheng; Yu, Tao; Shan, Ti-Dong; Li, Jie-Yao; Huang, Can-Ze; Zhong, Wa; Xia, Zhong-Sheng; Chen, Qi-Kui.

Afiliação

Ouyang H; Department of Gastroenterology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 Yan Jiang Xi Road, Guangzhou, 510120, Guangdong, People's Republic of China.
Yang HS; Department of Gastroenterology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 Yan Jiang Xi Road, Guangzhou, 510120, Guangdong, People's Republic of China.
Yu T; Department of Gastroenterology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 Yan Jiang Xi Road, Guangzhou, 510120, Guangdong, People's Republic of China. yutao2014@126.com.
Shan TD; Department of Gastroenterology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 Yan Jiang Xi Road, Guangzhou, 510120, Guangdong, People's Republic of China.
Li JY; Department of Gastroenterology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 Yan Jiang Xi Road, Guangzhou, 510120, Guangdong, People's Republic of China.
Huang CZ; Department of Gastroenterology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 Yan Jiang Xi Road, Guangzhou, 510120, Guangdong, People's Republic of China.
Zhong W; Department of Gastroenterology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 Yan Jiang Xi Road, Guangzhou, 510120, Guangdong, People's Republic of China.
Xia ZS; Department of Gastroenterology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 Yan Jiang Xi Road, Guangzhou, 510120, Guangdong, People's Republic of China.
Chen QK; Department of Gastroenterology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 Yan Jiang Xi Road, Guangzhou, 510120, Guangdong, People's Republic of China. qikuichen@yahoo.com.

Mol Cell Biochem ; 413(1-2): 165-78, 2016 Feb.

Article em En | MEDLINE | ID: mdl-26724951

Assuntos

Diabetes Mellitus Experimental/patologia; Células Epiteliais/citologia; Mucosa Intestinal/citologia; Sistema de Sinalização das MAP Quinases; Receptor de Insulina/metabolismo; Animais; Butadienos/administração & dosagem; Butadienos/farmacologia; Diferenciação Celular/efeitos dos fármacos; Linhagem Celular; Proliferação de Células/efeitos dos fármacos; Diabetes Mellitus Experimental/metabolismo; Células Epiteliais/efeitos dos fármacos; Células Epiteliais/metabolismo; Mucosa Intestinal/efeitos dos fármacos; Mucosa Intestinal/metabolismo; Sistema de Sinalização das MAP Quinases/efeitos dos fármacos; Camundongos; Nitrilas/administração & dosagem; Nitrilas/farmacologia; Isoformas de Proteínas/genética; Isoformas de Proteínas/metabolismo; Receptor de Insulina/genética; Estreptozocina

Palavras-chave

Diabetes mellitus; Differentiation; Insulin receptor; Intestinal epithelial cell; Proliferation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptor de Insulina / Sistema de Sinalização das MAP Quinases / Diabetes Mellitus Experimental / Células Epiteliais / Mucosa Intestinal Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Revista: Mol Cell Biochem Ano de publicação: 2016 Tipo de documento: Article

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