Hepatitis B Virus Infection of a Mouse Hepatic Cell Line Reconstituted with Human Sodium Taurocholate Cotransporting Polypeptide.
J Virol
; 90(9): 4827-4831, 2016 May.
Article
em En
| MEDLINE
| ID: mdl-26865711
ABSTRACT
Hepatitis B virus (HBV) enters hepatocytes via its receptor, human sodium taurocholate cotransporting polypeptide (hNTCP). So far, HBV infection has been achieved only in human hepatic cells reconstituted with hNTCP and not in cells of mouse origin. Here, the first mouse liver cell line (AML12) which gains susceptibility to HBV upon hNTCP expression is described. Thus, HBV infection of receptor-expressing mouse hepatocytes does not principally require a human cofactor but can be triggered by endogenous murine determinants.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vírus da Hepatite B
/
Transportadores de Ânions Orgânicos Dependentes de Sódio
/
Simportadores
/
Hepatite B
Limite:
Animals
/
Humans
Idioma:
En
Revista:
J Virol
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Alemanha