A Mechanism for Somatic Brain Mosaicism.

Weissman, Irving L; Gage, Fred H

Weissman, Irving L; Gage, Fred H.

Afiliação

Weissman IL; Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford University, Palo Alto, CA 94305, USA. Electronic address: irv@stanford.edu.
Gage FH; The Salk Institute for Biological Studies, Laboratory of Genetics, La Jolla, CA 92037, USA. Electronic address: gage@salk.edu.

Cell ; 164(4): 593-5, 2016 Feb 11.

Article em En | MEDLINE | ID: mdl-26871622

ABSTRACT

ABSTRACT

Double-strand break repair is required for neural development, and brain cells contain somatic genomic variations. Now, Wei et al. demonstrate that neural stem and progenitor cells undergo very frequent DNA breaks in a very restricted set of genes involved in neural cell adhesion and synapse function.

Assuntos

Quebras de DNA; Células-Tronco Neurais/metabolismo; Animais; Humanos

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quebras de DNA / Células-Tronco Neurais Limite: Animals / Humans Idioma: En Revista: Cell Ano de publicação: 2016 Tipo de documento: Article

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