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Blood lipid levels, statin therapy and the risk of intracerebral hemorrhage.
Ma, Yingxu; Li, Zhaokai; Chen, Liang; Li, Xiangping.
Afiliação
  • Ma Y; Department of Cardiology, The Second Xiangya Hospital, Central South University, #139 Middle Renmin Road, Changsha, Hunan, 410011, PR China.
  • Li Z; The Eight-Year Clinical Medicine of Grade 2012, Xiangya School of Medicine, Central South University, Changsha, Hunan, 410013, PR China.
  • Chen L; Department of Cardiology, The Second Xiangya Hospital, Central South University, #139 Middle Renmin Road, Changsha, Hunan, 410011, PR China.
  • Li X; The Eight-Year Clinical Medicine of Grade 2012, Xiangya School of Medicine, Central South University, Changsha, Hunan, 410013, PR China.
Lipids Health Dis ; 15: 43, 2016 Mar 01.
Article em En | MEDLINE | ID: mdl-26932585
Dyslipidemia has been proven to play an important role in the occurrence and development of the ischemic stroke and lipid-lowering therapy could significantly decrease the risk of the ischemic stroke. However, the association between lipid levels, lipid-lowering therapy and the risk of intracerebral hemorrhage (ICH) is not clear. Studies have shown that low serum levels of total cholesterol might be associated with increasing risk of ICH, whereas the SPARCL study, a large prospective, randomized, placebo-controlled trial, demonstrated an increased risk of hemorrhagic stroke during high-dose statin therapy among the patients with previous stroke. The relationship between lipid-lowering therapy and ICH has become a hot topic in the recent years. We searched PubMed for articles published in English to review the existing evidence on the association of lipid levels, statin therapy and risk of ICH as well as the underlying mechanisms in order to provide practical recommendations for clinical decision-making and a foundation for further researches.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hemorragia Cerebral / Inibidores de Hidroximetilglutaril-CoA Redutases / Hipolipemiantes Tipo de estudo: Clinical_trials / Etiology_studies / Guideline / Prognostic_studies / Risk_factors_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: Lipids Health Dis Assunto da revista: BIOQUIMICA / METABOLISMO Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hemorragia Cerebral / Inibidores de Hidroximetilglutaril-CoA Redutases / Hipolipemiantes Tipo de estudo: Clinical_trials / Etiology_studies / Guideline / Prognostic_studies / Risk_factors_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: Lipids Health Dis Assunto da revista: BIOQUIMICA / METABOLISMO Ano de publicação: 2016 Tipo de documento: Article