Mouse models for ROS1-fusion-positive lung cancers and their application to the analysis of multikinase inhibitor efficiency.

Inoue, Maki; Toki, Hideaki; Matsui, Junko; Togashi, Yuki; Dobashi, Akito; Fukumura, Ryutaro; Gondo, Yoichi; Minowa, Osamu; Tanaka, Norio; Mori, Seiichi; Takeuchi, Kengo; Noda, Tetsuo

Inoue, Maki; Toki, Hideaki; Matsui, Junko; Togashi, Yuki; Dobashi, Akito; Fukumura, Ryutaro; Gondo, Yoichi; Minowa, Osamu; Tanaka, Norio; Mori, Seiichi; Takeuchi, Kengo; Noda, Tetsuo.

Afiliação

Inoue M; Team for Advanced Development and Evaluation of Human Disease Models, RIKEN BioResource Center, Tsukuba 305-0074, Japan, Division of Cell Biology.
Toki H; Team for Advanced Development and Evaluation of Human Disease Models, RIKEN BioResource Center, Tsukuba 305-0074, Japan.
Matsui J; Team for Advanced Development and Evaluation of Human Disease Models, RIKEN BioResource Center, Tsukuba 305-0074, Japan.
Togashi Y; Pathology Project for Molecular Targets and Division of Pathology, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo 135-8550, Japan.
Dobashi A; Pathology Project for Molecular Targets and.
Fukumura R; Mutagenesis and Genomics Team, RIKEN BioResource Center, Tsukuba 305-0074, Japan and.
Gondo Y; Mutagenesis and Genomics Team, RIKEN BioResource Center, Tsukuba 305-0074, Japan and.
Minowa O; Team for Advanced Development and Evaluation of Human Disease Models, RIKEN BioResource Center, Tsukuba 305-0074, Japan.
Tanaka N; Project for Development of Innovative Research on Cancer Therapeutics, The Genome Center, Japanese Foundation for Cancer Research, Tokyo 135-8550, Japan.
Mori S; Project for Development of Innovative Research on Cancer Therapeutics, The Genome Center, Japanese Foundation for Cancer Research, Tokyo 135-8550, Japan.
Takeuchi K; Pathology Project for Molecular Targets and Division of Pathology, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo 135-8550, Japan.
Noda T; Team for Advanced Development and Evaluation of Human Disease Models, RIKEN BioResource Center, Tsukuba 305-0074, Japan, Division of Cell Biology, tnoda@jfcr.or.jp.

Carcinogenesis ; 37(5): 452-60, 2016 05.

Article em En | MEDLINE | ID: mdl-26964870

Assuntos

Neoplasias Hepáticas Experimentais/genética; Neoplasias Pulmonares/genética; Proteínas de Fusão Oncogênica/genética; Inibidores de Proteínas Quinases/farmacologia; Proteínas Tirosina Quinases/genética; Proteínas Proto-Oncogênicas/genética; Adenocarcinoma/genética; Adenocarcinoma/patologia; Adenocarcinoma de Pulmão; Adenoma/genética; Adenoma/patologia; Administração Oral; Animais; Antígenos de Diferenciação de Linfócitos B/genética; Crizotinibe; Fusão Gênica; Antígenos de Histocompatibilidade Classe II/genética; Humanos; Neoplasias Hepáticas Experimentais/tratamento farmacológico; Neoplasias Hepáticas Experimentais/patologia; Neoplasias Pulmonares/patologia; Camundongos Endogâmicos C57BL; Camundongos Transgênicos; Proteínas de Fusão Oncogênica/antagonistas & inibidores; Inibidores de Proteínas Quinases/administração & dosagem; Proteínas Tirosina Quinases/antagonistas & inibidores; Proteínas Proto-Oncogênicas/antagonistas & inibidores; Pirazóis/farmacologia; Piridinas/farmacologia; Sulfonas/farmacologia; Sindecana-4/genética; Triazinas/farmacologia

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Tirosina Quinases / Proteínas de Fusão Oncogênica / Proteínas Proto-Oncogênicas / Inibidores de Proteínas Quinases / Neoplasias Hepáticas Experimentais / Neoplasias Pulmonares Limite: Animals / Humans Idioma: En Revista: Carcinogenesis Ano de publicação: 2016 Tipo de documento: Article

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