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Brown Adipose Tissue Exhibits a Glucose-Responsive Thermogenic Biorhythm in Humans.
Lee, Paul; Bova, Ron; Schofield, Lynne; Bryant, Wendy; Dieckmann, William; Slattery, Anthony; Govendir, Matt A; Emmett, Louise; Greenfield, Jerry R.
Afiliação
  • Lee P; Diabetes and Metabolism Division, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia; Department of Endocrinology, St. Vincent's Hospital, Sydney, NSW 2010, Australia; Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia. Electronic address: p.lee@garvan.org
  • Bova R; Department of Surgery, St. Vincent's Hospital, Sydney, NSW 2010, Australia.
  • Schofield L; Diabetes and Metabolism Division, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia; Department of Endocrinology, St. Vincent's Hospital, Sydney, NSW 2010, Australia.
  • Bryant W; Diabetes Centre, St. Vincent's Hospital, Sydney, NSW 2010, Australia.
  • Dieckmann W; Department of Positron Emission Tomography, National Institutes of Health, Bethesda, MD 20892, USA.
  • Slattery A; Department of PET and Nuclear Medicine, St. Vincent's Hospital, Sydney, NSW 2010, Australia.
  • Govendir MA; Diabetes and Metabolism Division, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia.
  • Emmett L; Department of PET and Nuclear Medicine, St. Vincent's Hospital, Sydney, NSW 2010, Australia.
  • Greenfield JR; Diabetes and Metabolism Division, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia; Department of Endocrinology, St. Vincent's Hospital, Sydney, NSW 2010, Australia; Diabetes Centre, St. Vincent's Hospital, Sydney, NSW 2010, Australia; Faculty of Medicine, University of New South Wa
Cell Metab ; 23(4): 602-9, 2016 Apr 12.
Article em En | MEDLINE | ID: mdl-26972823
High abundance of brown adipose tissue (BAT) is linked to lower glycaemia in humans, leading to the belief that BAT may protect against diabetes. The relationship between BAT glucose utilization and systemic glucose homeostasis has not been defined. In this paper we have characterized glycaemic excursions and BAT thermogenic responses in human brown adipocytes, BAT explants, and healthy adults through supraclavicular temperature profiling, revealing their circadian coupling in vivo and in vitro, orchestrated by UCP1, GLUT4, and Rev-erbα biorhythms. Extent of glycated haemoglobin also correlated positively with environmental temperature among community-dwelling patients. These data uncover potential crosstalk between BAT and glucose regulatory pathways, evident on cellular, tissue, individual, and population levels, and provide impetus to search for BAT harnessing strategies for therapeutic purposes.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tecido Adiposo Marrom / Ritmo Circadiano / Termogênese / Glucose Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Cell Metab Assunto da revista: METABOLISMO Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tecido Adiposo Marrom / Ritmo Circadiano / Termogênese / Glucose Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Cell Metab Assunto da revista: METABOLISMO Ano de publicação: 2016 Tipo de documento: Article