Epsilon-Aminocaproic Acid Has No Association With Thromboembolic Complications, Renal Failure, or Mortality After Liver Transplantation.
J Cardiothorac Vasc Anesth
; 30(4): 917-23, 2016 Aug.
Article
em En
| MEDLINE
| ID: mdl-27020101
ABSTRACT
OBJECTIVES:
To examine the role of epsilon-aminocaproic acid (EACA) administered after reperfusion of the donor liver in the incidences of thromboembolic events and acute kidney injury within 30 days after orthotopic liver transplantation. One-year survival rates between the EACA-treated and EACA-nontreated groups also were examined.DESIGN:
Retrospective, observational, cohort study design.SETTING:
Single-center, university hospital.PARTICIPANTS:
The study included 708 adult liver transplantations performed from 2008 to 2013.INTERVENTIONS:
None. MEASUREMENTS AND MAINRESULTS:
EACA administration was not associated with incidences of intracardiac thrombosis/pulmonary embolism (1.3%) or intraoperative death (0.6%). Logistic regression (n = 708) revealed 2 independent risk factors associated with myocardial ischemia (age and pre-transplant vasopressor use) and 8 risk factors associated with the need for post-transplant dialysis (age, female sex, redo orthotopic liver transplantation, preoperative sodium level, pre-transplant acute kidney injury or dialysis, platelet transfusion, and re-exploration within the first week after transplant); EACA was not identified as a risk factor for either outcome. One-year survival rates were similar between groups 92% in EACA-treated group versus 93% in the EACA-nontreated group.CONCLUSIONS:
The antifibrinolytic, EACA, was not associated with an increased incidence of thromboembolic complications or postoperative acute kidney injury, and it did not alter 1-year survival after liver transplantation.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tromboembolia
/
Transplante de Fígado
/
Injúria Renal Aguda
/
Ácido Aminocaproico
/
Antifibrinolíticos
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Cardiothorac Vasc Anesth
Assunto da revista:
ANESTESIOLOGIA
/
CARDIOLOGIA
Ano de publicação:
2016
Tipo de documento:
Article